Fiserova-Bergerova V, Pierce J T, Droz P O
Department of Anesthesiology, University of Miami School of Medicine, FL 33101.
Am J Ind Med. 1990;17(5):617-35. doi: 10.1002/ajim.4700170507.
A dermal penetration rate (flux), predicted from physical properties of 132 chemicals, is suggested as an index of the dermal absorption potential of industrial chemicals. The prediction is designed for organic nonelectrolytes. Two reference values are recommended as criteria for skin notation: 1) dermal absorption potential, which relates to dermal absorption raising the dose of nonvolatile chemicals or biological levels of volatile chemicals 30% above those observed during inhalation exposure to TLV-TWA only--dermal absorption of chemicals belonging to this category should be considered when data obtained by biological monitoring are interpreted; and 2) dermal toxicity potential, which relates to dermal absorption that triples biological levels as compared with levels observed during inhalation exposure to TLV-TWA only. Chemicals belonging in this category should carry a skin notation. The toxicity criteria may not be valid for chemicals whose TLVs are based on preventing irritation and discomfort.
根据132种化学物质的物理性质预测的皮肤渗透速率（通量），被建议作为工业化学品皮肤吸收潜力的指标。该预测针对有机非电解质。推荐了两个参考值作为皮肤标注标准：1）皮肤吸收潜力，它与皮肤吸收使非挥发性化学品的剂量或挥发性化学品的生物水平比仅吸入接触阈限值-时间加权平均值（TLV-TWA）时观察到的水平提高30%相关——在解释生物监测获得的数据时，应考虑属于此类别的化学品的皮肤吸收；2）皮肤毒性潜力，它与皮肤吸收使生物水平比仅吸入接触TLV-TWA时观察到的水平增加两倍相关。属于此类别的化学品应带有皮肤标注。对于其TLV基于预防刺激和不适的化学品，毒性标准可能无效。
