Jäppinen P, Tola S
Occupational Health Centre, Enso-Gutzeit Oy, Imatra, Finland.
Br J Ind Med. 1990 Apr;47(4):259-62. doi: 10.1136/oem.47.4.259.
A mortality study, concentrating on cardiovascular mortality, was undertaken among Finnish sulphite mill workers exposed to sulphur dioxide and sulphate mill workers exposed to hydrogen sulphide and organic sulphides. They had been employed continuously for at least one year between 1945 and 1961. National death rates were used for comparison and mortality was followed up until 31 December 1981. Among the cohort exposed to sulphur dioxide (2268 person-years), an excess of cardiovascular deaths was noticed among the men (24 obs, 19.4 exp, SMR 123) due to an excess of coronary deaths (18 obs, 12.4 exp, SMR 145). The cardiovascular mortality was not affected by the duration of occupational exposure or follow up period in this cohort. Among the men exposed to hydrogen sulphide and organic sulphides (4179 person-years), there was also an excess of cardiovascular deaths (37 obs, 24.7 exp, SMR 150) due to an excess of coronary deaths (25 obs, 16.7 exp, SMR 150). These excesses increased with longer follow up period. As common risk factors of coronary heart disease could not explain the findings in the sulphate mill cohort, they may be associated with exposure to hydrogen sulphide and organic sulphides.
一项针对心血管疾病死亡率的研究在芬兰的亚硫酸盐工厂工人(接触二氧化硫)和硫酸盐工厂工人(接触硫化氢和有机硫化物)中展开。这些工人在1945年至1961年期间连续受雇至少一年。研究采用全国死亡率进行比较,并对死亡率进行随访直至1981年12月31日。在接触二氧化硫的队列(2268人年)中,男性心血管疾病死亡人数过多(观察到24例,预期19.4例,标准化死亡比123),原因是冠心病死亡人数过多(观察到18例,预期12.4例,标准化死亡比145)。在该队列中,职业接触时长或随访时间对心血管疾病死亡率没有影响。在接触硫化氢和有机硫化物的男性队列(4179人年)中,同样存在心血管疾病死亡人数过多的情况(观察到37例,预期24.7例,标准化死亡比150),原因是冠心病死亡人数过多(观察到25例,预期16.7例,标准化死亡比150)。随着随访时间延长,这些过多的死亡人数有所增加。由于冠心病的常见风险因素无法解释硫酸盐工厂队列中的研究结果,这些结果可能与接触硫化氢和有机硫化物有关。