Department of Radiology, Mayo Clinic, Rochester, MN, USA.
Alzheimers Dement. 2013 Oct;9(5 Suppl):S116-23. doi: 10.1016/j.jalz.2012.10.011. Epub 2013 Jan 30.
Prevalence and risk factors for focal hemosiderin deposits are important considerations when planning amyloid-modifying trials for treatment and prevention of Alzheimer's disease (AD).
Subjects were cognitively normal (n = 171), early-mild cognitive impairment (MCI) (n = 240), late-MCI (n = 111), and AD (n = 40) from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Microhemorrhages and superficial siderosis were assessed at baseline and on all available MRIs at 3, 6, and 12 months. β-amyloid load was assessed with (18)F-florbetapir positron emission tomography.
Prevalence of superficial siderosis was 1% and prevalence of microhemorrhages was 25% increasing with age (P < .001) and β-amyloid load (P < .001). Topographic densities of microhemorrhages were highest in the occipital lobes and lowest in the deep/infratentorial regions. A greater number of microhemorrhages at baseline was associated with a greater annualized rate of additional microhemorrhages by last follow-up (rank correlation = 0.49; P < .001).
Focal hemosiderin deposits are relatively common in the ADNI cohort and are associated with β-amyloid load.
在计划用于治疗和预防阿尔茨海默病（AD）的淀粉样蛋白修饰试验时，局灶性含铁血黄素沉积的患病率和危险因素是重要的考虑因素。
受试者来自阿尔茨海默病神经影像学倡议（ADNI），包括认知正常（n = 171）、早期轻度认知障碍（MCI）（n = 240）、晚期 MCI（n = 111）和 AD（n = 40）。在基线和所有可用的 MRI 上（3、6 和 12 个月）评估微出血和表浅铁沉积。β-淀粉样蛋白负荷用（18）F-氟比他滨正电子发射断层扫描评估。
表浅铁沉积的患病率为 1%，微出血的患病率为 25%，随年龄增加（P <.001）和β-淀粉样蛋白负荷增加（P <.001）而增加。微出血的分布密度在枕叶最高，在深部/幕下区域最低。基线时微出血数量较多与最后一次随访时更多的微出血年增长率相关（等级相关= 0.49；P <.001）。
局灶性含铁血黄素沉积在 ADNI 队列中较为常见，与β-淀粉样蛋白负荷相关。
