Department of Dermatology, Mie University Graduate School of Medicine, Mie, Tsu, Japan.
Int J Hematol. 2013 Mar;97(3):345-50. doi: 10.1007/s12185-013-1277-0. Epub 2013 Feb 3.
Antiphospholipid antibodies (aPL) including lupus anticoagulant (LA), anticardiolipin antibodies (aCL) IgG and aCL-β2-glycoprotein I (β2GPI) complex IG are causative factors for thrombotic event (THE). We retrospectively investigated relationships between aPLs and THE in 458 patients suspected of having antiphospholipid syndrome. THEs were observed in 232 of 458 patients, including 148 cases of venous thrombosis, 59 of arterial thrombosis, 18 of microthrombosis, and 20 of complications of pregnancy. The frequency of THE was significantly high in patients positive for LA and/or aPL. In patients with autoimmune disease (AID), the frequency of THE was significantly high in patients with any types of aPLs. Additionally, risk of THE was significantly increased in patients with more than two types of aPLs. Prolonged activated partial thromboplastin time indicated a high risk for THE. However, neither thrombocytopenia nor AID was a risk for THE. In conclusion, the presence of aPL is an indicator for high risk of THE in patients in whom THE was suspected. However, the risk of THE in aPL-positive patients varied among patients with different underlying diseases.
抗磷脂抗体（aPL）包括狼疮抗凝物（LA）、抗心磷脂抗体（aCL）IgG 和β2-糖蛋白 I（β2GPI）复合物 Ig，是血栓事件（THE）的致病因素。我们回顾性调查了 458 例疑似抗磷脂综合征患者的 aPL 与 THE 之间的关系。在 458 例患者中观察到 232 例 THE，包括 148 例静脉血栓形成、59 例动脉血栓形成、18 例微血栓形成和 20 例妊娠并发症。LA 和/或 aPL 阳性患者的 THE 发生率显著升高。在自身免疫性疾病（AID）患者中，任何类型的 aPL 患者的 THE 发生率均显著升高。此外，aPL 类型超过两种的患者发生 THE 的风险显著增加。延长的活化部分凝血活酶时间表明 THE 风险较高。然而，血小板减少症和 AID 均不是 THE 的危险因素。总之，在疑似 THE 的患者中，存在 aPL 是 THE 高风险的指标。然而，aPL 阳性患者的 THE 风险在不同基础疾病的患者中存在差异。
