Gargiulo Sara, Greco Adelaide, Gramanzini Matteo, Esposito Silvia, Affuso Andrea, Brunetti Arturo, Vesce Giancarlo
Bioimaging and Biostructures Institute, Italian National Council of Research, Naples, Italy.
ILAR J. 2012;53(1):E70-81. doi: 10.1093/ilar.53.1.70.
Animal experiments are necessary for a better understanding of diseases and for developing new therapeutic strategies. The mouse (Mus musculus) is currently the most popular laboratory animal in biomedical research. Mice imaging procedures are increasingly used in preclinical research because they allow in vivo monitoring and they are readily available for longitudinal and noninvasive studies as well as investigations into the evolution of diseases and the effects of new therapies. New imaging techniques and sophisticated laboratory animal imaging tools are currently producing a large body of evidence about the possible interference of anesthesia with different imaging methods that have the potential to compromise the results of in vivo studies. The purpose of this article is to review the existing literature on molecular imaging studies in mice, to describe the effects of different anesthetic protocols on their outcome, and to report our own experience with such studies.
动物实验对于更好地理解疾病和开发新的治疗策略是必要的。小鼠（小家鼠）是目前生物医学研究中最受欢迎的实验动物。小鼠成像程序在临床前研究中越来越多地被使用，因为它们允许进行体内监测，并且很容易用于纵向和非侵入性研究，以及对疾病演变和新疗法效果的研究。新的成像技术和先进的实验动物成像工具目前正在产生大量证据，表明麻醉可能会干扰不同的成像方法，而这些成像方法有可能影响体内研究的结果。本文的目的是回顾现有的关于小鼠分子成像研究的文献，描述不同麻醉方案对其结果的影响，并报告我们自己在这类研究中的经验。
