Fteropoulli Theodora, Stygall Jan, Cullen Shay, Deanfield John, Newman Stanton P
Centre for Health Services Research, School of Health Sciences, City University London, London, United Kingdom.
Cardiol Young. 2013 Aug;23(4):473-85. doi: 10.1017/S1047951112002351. Epub 2013 Feb 6.
This review explores the quality of life of adult congenital heart disease patients and the relationship between disease severity and quality of life.
We searched seven electronic databases and the bibliography of articles. The 31 selected studies fulfilled the following criteria: adult population; quantitative; assessment of quality of life and/or impact of disease severity on quality of life using validated measures; English language. Data extraction forms were used to summarise the results.
There are evident methodological limitations within the reviewed studies such as heterogeneous populations, designs, and quality of life conceptualisations and measurements. Despite these problems, findings suggest that the quality of life of adult congenital heart disease patients is compromised in the physical domain compared with their healthy counterparts, whereas no differences were found in relation to the psychosocial and environmental/occupational domain. Some severity variables appear to be significant correlates of quality of life and could be considered in a future standardised classification of disease severity.
The methodological limitations of past research in relation to the definition and measurement of quality of life, the study designs, and disease severity classifications need to be addressed in future studies in order to provide robust evidence and valid conclusions in this area of study. This will enable the development of targeted interventions for the improvement of quality of life in the adult population of congenital heart disease patients.
本综述探讨成人先天性心脏病患者的生活质量以及疾病严重程度与生活质量之间的关系。
我们检索了七个电子数据库以及文章的参考文献。入选的31项研究符合以下标准：成年人群；定量研究；使用经过验证的方法评估生活质量和/或疾病严重程度对生活质量的影响；英文文献。采用数据提取表来总结结果。
所综述的研究存在明显的方法学局限性，如人群、设计以及生活质量概念化和测量方法的异质性。尽管存在这些问题，但研究结果表明，与健康同龄人相比，成人先天性心脏病患者在身体领域的生活质量受到损害，而在心理社会和环境/职业领域未发现差异。一些严重程度变量似乎与生活质量显著相关，可在未来疾病严重程度的标准化分类中予以考虑。
过去关于生活质量定义和测量、研究设计以及疾病严重程度分类的研究存在方法学局限性，未来研究需要加以解决，以便在该研究领域提供有力证据和有效结论。这将有助于制定有针对性的干预措施，以改善成人先天性心脏病患者的生活质量。
