Faculty of Engineering and Institute of Nanotechnology and Advanced Materials, Bar-Ilan University , Ramat-Gan, 5290002, Israel.
Nano Lett. 2014 May 14;14(5):2681-7. doi: 10.1021/nl500573d. Epub 2014 Apr 8.
In this study we report the use of gold nanorods (GNRs) as absorption contrast agents in the diffusion reflection (DR) method for the in vivo detection of atherosclerotic injury. The early detection and characterization of atherosclerotic vascular disease is considered to be one of the greatest medical challenges today. We show that macrophage cells, which are major components of unstable active atherosclerotic plaques, uptake gold nanoparticles, resulting in a change in the optical properties of tissue-like phantoms and a unique DR profile. In vivo DR measurements of rats that underwent injury of the carotid artery showed a clear difference between the DR profiles of the injured compared with healthy arteries. The results suggest that DR measurements following GNRs administration represent a potential novel method for the early detection of atherosclerotic vascular disease.
在这项研究中，我们报告了使用金纳米棒（GNRs）作为扩散反射（DR）方法中的吸收对比剂，用于体内检测动脉粥样硬化损伤。动脉粥样硬化血管疾病的早期检测和特征描述被认为是当今最大的医学挑战之一。我们表明，巨噬细胞是不稳定的活跃动脉粥样硬化斑块的主要成分，摄取金纳米颗粒，导致类似组织的体模的光学性质发生变化，并产生独特的 DR 特征。对颈动脉损伤的大鼠进行体内 DR 测量，结果表明损伤动脉与健康动脉的 DR 特征之间存在明显差异。结果表明，GNRs 给药后的 DR 测量可能是早期检测动脉粥样硬化血管疾病的一种新方法。
