College of Pharmacy, Sookmyung Women's University, Chungpa-Dong, Yongsan-Ku, Seoul, South Korea.
Adv Exp Med Biol. 2013;776:189-98. doi: 10.1007/978-1-4614-6093-0_19.
Taurine is a nonessential amino acid and has a variety of physiological and pharmacological effects. Recently, protective effects of taurine against anticancer drugs on normal cells were investigated. But anticancer effects of taurine on cancer cells remain poorly understood. Therefore, we investigated the anticancer effects of taurine alone and combination of cisplatin with taurine in human cervical cancer cells. Single treatment of taurine decreased cell proliferation in a time- and dose-dependent manner. In co-treatment of cisplatin with taurine, cell proliferation was more decreased than single treatment of cisplatin. Reduced cell proliferation was caused by apoptosis induction. Thus, after treatment of cisplatin with taurine, apoptotic cells were investigated. Apoptotic cells were increased more than taurine or cisplatin alone. Induction of apoptosis was related to p53 expression and activation of caspase-3, caspase-6, caspase-7, and caspase-9. In present study, the results indicated that co-treatment of cisplatin with taurine was more effective than single treatment of cisplatin.
牛磺酸是一种非必需氨基酸，具有多种生理和药理作用。最近，研究了牛磺酸对正常细胞的抗癌药物的保护作用。但是，牛磺酸对癌细胞的抗癌作用仍知之甚少。因此，我们研究了牛磺酸单独和与顺铂联合治疗人宫颈癌细胞的抗癌作用。牛磺酸单独处理可时间和剂量依赖性地降低细胞增殖。顺铂与牛磺酸联合处理时，细胞增殖比单独用顺铂处理时降低更多。细胞增殖减少是由细胞凋亡诱导引起的。因此，在用顺铂处理牛磺酸后，研究了凋亡细胞。凋亡细胞的增加比牛磺酸或顺铂单独处理时更多。凋亡的诱导与 p53 表达和 caspase-3、caspase-6、caspase-7 和 caspase-9 的激活有关。在本研究中，结果表明顺铂与牛磺酸联合处理比单独用顺铂处理更有效。
