Young S R, Dyson M
Department of Anatomy, United Medical School of Guy Hospital, London, UK.
Ultrasonics. 1990 May;28(3):175-80. doi: 10.1016/0041-624x(90)90082-y.
The effect of therapeutic ultrasound on the healing of the dermis of full-thickness excised lesions made in the flank skin of adult rats was assessed quantitatively by means of differential cell counts made in sections of the wound bed five and seven days after injury. Wounds were either sham-treated (control group) or exposed to pulsed ultrasound (2 ms on, 8 ms off) at an intensity of 0.1 W cm-2 SATA (frequency either 0.75 MHz or 3.0 MHz). By five days after injury, ultrasound-treated wounds contained more extensive granulation tissue, fewer polymorphonuclear leucocytes (polymorphs) and macrophages, and more fibroblasts (aligned in a manner conducive to efficient wound contraction) than the sham-irradiated controls. By seven days after injury there was no significant difference in cellularity between the controls and the ultrasonically-irradiated wounds. The results obtained suggest that ultrasound therapy can be useful in accelerating the inflammatory and early proliferative stages of repair.
通过对成年大鼠侧腹皮肤全层切除损伤创面床在损伤后5天和7天的切片进行细胞差异计数，定量评估了治疗性超声对其真皮愈合的影响。伤口要么进行假治疗（对照组），要么以0.1 W/cm² SATA的强度暴露于脉冲超声（开2 ms，关8 ms）（频率为0.75 MHz或3.0 MHz）。损伤后5天，与假照射对照组相比，超声治疗的伤口含有更广泛的肉芽组织、更少的多形核白细胞（多形核细胞）和巨噬细胞，以及更多的成纤维细胞（排列方式有利于有效伤口收缩）。损伤后7天，对照组和超声照射伤口之间的细胞数量没有显著差异。所得结果表明，超声治疗有助于加速修复的炎症和早期增殖阶段。
