Sin Y M, Sedgwick A D, Chea E P, Willoughby D A
Ann Rheum Dis. 1986 Oct;45(10):873-7. doi: 10.1136/ard.45.10.873.
Connective tissue mast cells were topographically and quantitatively studied in the newly formed lining tissue of six day old air pouches induced in the dorsal surface of mice. The results showed that the number of mast cells in the cavities innermost lining increased after injection of carrageenan into the cavity. Degranulation of mast cells was also observed. Variations in mast cell numbers in the lining seemed to correlate with the histamine content. These findings suggest that mast cells not only participate in the initiation of the early phase of acute inflammation but also appear to play an important part in regulating and prolonging more chronic inflammatory reactions.
对在小鼠背部诱导形成的6日龄气囊肿新形成的衬里组织中的结缔组织肥大细胞进行了局部解剖学和定量研究。结果显示，向囊腔内注射角叉菜胶后，囊腔最内层衬里中的肥大细胞数量增加。还观察到肥大细胞脱颗粒现象。衬里中肥大细胞数量的变化似乎与组胺含量相关。这些发现表明，肥大细胞不仅参与急性炎症早期阶段的起始过程，而且似乎在调节和延长更慢性的炎症反应中发挥重要作用。
