氢化可的松局部给药对体内软骨降解的影响。
Effects of local administration of hydrocortisone on cartilage degradation in vivo.
作者信息
Sedgwick A D, Sin Y M, Moore A R, Edwards J C, Willoughby D A
出版信息
Ann Rheum Dis. 1984 Jun;43(3):418-20. doi: 10.1136/ard.43.3.418.
Abstract
The effect of corticosteroid on autologous minced cartilage transplanted into facsimile synovial cavities has been studied. The soluble form of hydrocortisone, as the sodium succinate, reduced proteoglycan loss from cartilage in a dose-dependent manner. In contrast, insoluble hydrocortisone acetate, if given directly into the cartilage-containing cavity, enhanced proteoglycan loss. Injection of the same dose of drug into the inflamed lining tissue reversed this effect. These findings suggest that intra-articular steroid injection may enhance cartilage damage if insoluble preparations are used, but that this may be overcome by injecting into the inflamed lining tissue rather than into the cavity itself.
摘要
已经研究了皮质类固醇对移植到模拟滑膜腔中的自体切碎软骨的影响。氢化可的松的可溶性形式，即琥珀酸钠，以剂量依赖的方式减少了软骨中蛋白聚糖的损失。相比之下，不溶性醋酸氢化可的松如果直接注入含软骨的腔内，则会增加蛋白聚糖的损失。将相同剂量的药物注入发炎的衬里组织可逆转这种效果。这些发现表明，如果使用不溶性制剂，关节内注射类固醇可能会加重软骨损伤，但通过注入发炎的衬里组织而非腔本身，这种情况可能会得到克服。
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