Trad B, Ben Hassine H, Khalifa M, Idriss N, Slama F, Bahri F, Laouani Kechrid C, Boukadida J, Sghiri R
Laboratory of Microbiology-Immunology, Farhat Hached Hospital, Ibn Al Jazzar street, 4000 Sousse, Tunisia.
Pathol Biol (Paris). 2013 Jun;61(3):113-6. doi: 10.1016/j.patbio.2013.01.007. Epub 2013 Feb 8.
The presence of a wide variety of autoantibodies is a characteristic feature of systemic lupus erythematosus (SLE). Although non-specific, anti-complement C1q (anti-C1q) were shown to correlate with the occurrence of active nephritis. The present study aimed to investigate the prevalence of anti-C1q in Tunisian SLE patients and their association with clinical manifestations, especially renal involvement.
IgG anti-C1q antibodies were assessed by Elisa in 98 SLE patients, 55 patients with rheumatoid arthritis (RA) and 65 healthy individuals (HI).
Anti-C1q were found in 53 (54.1%) patients with SLE, three (5%) patients with RA and six (9.3%) HI. Among the 65 patients with renal involvement, anti-C1q were present in 35 (53.8%) patients. There was no significant association between anti-C1q and renal or extrarenal manifestations. In addition, there was no correlation between anti-C1q titer and SLEDAI index. Anti-C1q were significantly associated with anti-nucleosome (P=0.001), anti-Sm (P=0.01) and a low C4 level (P=0.046). Concomitant presence of anti-C1q and anti-dsDNA antibodies was not associated with renal manifestations.
Our study shows that prevalence of anti-C1q was comparable with that previously reported in Caucasian populations. These antibodies were associated with a low C4 level. However, there was no association between anti-C1q and renal involvement or severity of nephritis.
存在多种自身抗体是系统性红斑狼疮（SLE）的一个特征。尽管非特异性，但抗补体C1q（抗C1q）已显示与活动性肾炎的发生相关。本研究旨在调查突尼斯SLE患者中抗C1q的患病率及其与临床表现，尤其是肾脏受累的关联。
采用酶联免疫吸附测定法（ELISA）评估98例SLE患者、55例类风湿关节炎（RA）患者和65名健康个体（HI）的IgG抗C1q抗体。
53例（54.1%）SLE患者、3例（5%）RA患者和6例（9.3%）HI检测到抗C1q。在65例有肾脏受累的患者中，35例（53.8%）存在抗C1q。抗C1q与肾脏或肾外表现之间无显著关联。此外，抗C1q滴度与SLE疾病活动指数（SLEDAI）无相关性。抗C1q与抗核小体（P = 0.001）、抗Sm（P = 0.01）及低C4水平（P = 0.046）显著相关。抗C1q和抗双链DNA（dsDNA）抗体同时存在与肾脏表现无关。
我们的研究表明，抗C1q的患病率与先前在白种人群中报道的相当。这些抗体与低C4水平相关。然而，抗C1q与肾脏受累或肾炎严重程度之间无关联。
