Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.
Clin Chem. 2013 Apr;59(4):617-28. doi: 10.1373/clinchem.2012.187617. Epub 2013 Feb 11.
Obesity, metabolic syndrome, and type 2 diabetes are major public health challenges. Recently, interest has surged regarding the possible role of the intestinal microbiota as potential novel contributors to the increased prevalence of these 3 disorders.
Recent advances in microbial DNA sequencing technologies have resulted in the widespread application of whole-genome sequencing technologies for metagenomic DNA analysis of complex ecosystems such as the human gut. Current evidence suggests that the gut microbiota affect nutrient acquisition, energy harvest, and a myriad of host metabolic pathways.
Advances in the Human Microbiome Project and human metagenomics research will lead the way toward a greater understanding of the importance and role of the gut microbiome in metabolic disorders such as obesity, metabolic syndrome, and diabetes.
肥胖症、代谢综合征和 2 型糖尿病是重大的公共健康挑战。最近，人们对肠道微生物组可能作为这三种疾病发病率上升的潜在新因素的作用产生了浓厚的兴趣。
微生物 DNA 测序技术的最新进展使得全基因组测序技术广泛应用于人类肠道等复杂生态系统的宏基因组 DNA 分析。目前的证据表明，肠道微生物组会影响营养物质的获取、能量的收获以及宿主代谢途径的多样性。
人类微生物组计划和人类宏基因组学研究的进展将有助于更好地理解肠道微生物组在肥胖症、代谢综合征和糖尿病等代谢紊乱中的重要性和作用。
