Fulda Simone
Institute for Experimental Cancer Research in Pediatrics, Goethe-University Frankfurt, Komturstraße 3a, 60528 Frankfurt, Germany.
Int J Cell Biol. 2013;2013:463637. doi: 10.1155/2013/463637. Epub 2013 Jan 21.
While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells. Key discoveries in the field of cell death research, including the identification of critical components of the necroptotic machinery, led to a revised concept of cell death signaling programs. Several regulatory check and balances are in place in order to ensure that necroptosis is tightly controlled according to environmental cues and cellular needs. This network of regulatory mechanisms includes metabolic pathways, especially those linked to mitochondrial signaling events. A better understanding of these signal transduction mechanisms will likely contribute to open new avenues to exploit our knowledge on the regulation of necroptosis signaling for therapeutic application in the treatment of human diseases.
长期以来，坏死性凋亡一直被视为由物理或化学损伤引发的一种意外的细胞死亡方式，但在过去几年中，很明显坏死性凋亡在哺乳动物细胞中也可能是一种程序性细胞死亡形式。细胞死亡研究领域的关键发现，包括坏死性凋亡机制关键成分的鉴定，导致了细胞死亡信号程序概念的修订。为确保坏死性凋亡根据环境线索和细胞需求得到严格控制，存在多种调节性的制衡机制。这种调节机制网络包括代谢途径，尤其是那些与线粒体信号事件相关的途径。更好地理解这些信号转导机制可能有助于开辟新途径，利用我们对坏死性凋亡信号调节的认识，将其应用于人类疾病治疗的治疗应用中。
