Institute of Environmental Science for Human Life, Ochanomizu University, Bunkyo-ku, Tokyo, Japan.
Eur J Clin Nutr. 2013 May;67(5):532-5. doi: 10.1038/ejcn.2013.29. Epub 2013 Feb 13.
Polyphenols are common constituents of the diet, and research on their health benefits has developed quickly over the past few years. Our purpose is to review recent findings highlighting daily dietary polyphenol intake and the diverse function of polyphenols and their possible relationships to cardiovascular disease (CVD). Several cohort studies have reported an inverse relationship between the daily consumption of polyphenols and CVD risk. Many studies showed that beverages could be a large source of polyphenols. Our previous findings provide that Japanese people intake polyphenols mainly from beverages, especially coffee and green tea (in descending order of polyphenol content). Many kinds of polyphenols act as an antioxidant against low-density lipoprotein oxidation, which is known to promote atherosclerosis. Recent accumulating evidence suggests that dietary polyphenols could exert their cardioprotective actions through their potential to improve metabolic disorder and vascular inflammation. These findings raise the possibility that polyphenols have a wide variety of roles in the intestine, liver and vascular tissue. In addition to identifying mechanisms of polyphenol bioactivity by basic research, much more epidemiological and clinical evidence linking reduced cardiovascular risk with dietary polyphenols intake are needed.
多酚是饮食中的常见成分，近年来，关于其对健康益处的研究发展迅速。我们的目的是综述最近的研究结果，强调日常饮食中多酚的摄入量以及多酚的多种功能及其与心血管疾病（CVD）的可能关系。一些队列研究报告称，多酚的日摄入量与 CVD 风险呈负相关。许多研究表明，饮料可能是多酚的主要来源。我们之前的研究结果表明，日本人主要从饮料中摄取多酚，尤其是咖啡和绿茶（按多酚含量降序排列）。许多种多酚可以作为一种抗氧化剂来对抗低密度脂蛋白的氧化，而这种氧化被认为会促进动脉粥样硬化。最近不断增加的证据表明，膳食多酚可以通过改善代谢紊乱和血管炎症来发挥其心脏保护作用。这些发现提出了这样一种可能性，即多酚在肠道、肝脏和血管组织中可能具有广泛的作用。除了通过基础研究来确定多酚生物活性的机制外，还需要更多的流行病学和临床证据来证明减少心血管风险与摄入膳食多酚之间的关联。
