• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

痤疮丙酸杆菌发酵，一种人类皮肤微生物组中的共生菌，作为皮肤益生菌对抗耐甲氧西林金黄色葡萄球菌。

Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus.

机构信息

Division of Dermatology, Department of Medicine, University of California San Diego, La Jolla, CA, USA.

出版信息

PLoS One. 2013;8(2):e55380. doi: 10.1371/journal.pone.0055380. Epub 2013 Feb 6.

DOI:10.1371/journal.pone.0055380
PMID:23405142
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3566139/
Abstract

Bacterial interference creates an ecological competition between commensal and pathogenic bacteria. Through fermentation of milk with gut-friendly bacteria, yogurt is an excellent aid to balance the bacteriological ecosystem in the human intestine. Here, we demonstrate that fermentation of glycerol with Propionibacterium acnes (P. acnes), a skin commensal bacterium, can function as a skin probiotic for in vitro and in vivo growth suppression of USA300, the most prevalent community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA). We also promote the notion that inappropriate use of antibiotics may eliminate the skin commensals, making it more difficult to fight pathogen infection. This study warrants further investigation to better understand the role of fermentation of skin commensals in infectious disease and the importance of the human skin microbiome in skin health.

摘要

细菌干扰在共生菌和病原菌之间创造了一种生态竞争。通过利用肠道友好细菌发酵牛奶，酸奶成为平衡人类肠道细菌生态系统的极佳辅助手段。在这里，我们证明了利用皮肤共生菌痤疮丙酸杆菌（P. acnes）发酵甘油可以作为一种皮肤益生菌，抑制社区获得性耐甲氧西林金黄色葡萄球菌（CA-MRSA）中最常见的 USA300 在体外和体内的生长。我们还提出了一种观点，即抗生素的不当使用可能会消除皮肤共生菌，从而使对抗病原体感染更加困难。这项研究值得进一步研究，以更好地了解皮肤共生菌发酵在传染病中的作用，以及人类皮肤微生物组在皮肤健康中的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/90c84d0a4535/pone.0055380.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/3b8da1310862/pone.0055380.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/0298f7a782d9/pone.0055380.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/a53609ad7d9d/pone.0055380.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/83c0fa51f634/pone.0055380.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/90c84d0a4535/pone.0055380.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/3b8da1310862/pone.0055380.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/0298f7a782d9/pone.0055380.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/a53609ad7d9d/pone.0055380.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/83c0fa51f634/pone.0055380.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da87/3566139/90c84d0a4535/pone.0055380.g005.jpg

相似文献

1
Fermentation of Propionibacterium acnes, a commensal bacterium in the human skin microbiome, as skin probiotics against methicillin-resistant Staphylococcus aureus.痤疮丙酸杆菌发酵，一种人类皮肤微生物组中的共生菌，作为皮肤益生菌对抗耐甲氧西林金黄色葡萄球菌。
PLoS One. 2013;8(2):e55380. doi: 10.1371/journal.pone.0055380. Epub 2013 Feb 6.
2
Commensal Provokes Immunity to Protect against Skin Infection of Methicillin-Resistant .共生菌引发免疫反应以预防耐甲氧西林金黄色葡萄球菌皮肤感染
Int J Mol Sci. 2018 Apr 25;19(5):1290. doi: 10.3390/ijms19051290.
3
Staphylococcus epidermidis in the human skin microbiome mediates fermentation to inhibit the growth of Propionibacterium acnes: implications of probiotics in acne vulgaris.表皮葡萄球菌在人类皮肤微生物组中介导发酵以抑制痤疮丙酸杆菌的生长：益生菌在寻常痤疮中的意义。
Appl Microbiol Biotechnol. 2014 Jan;98(1):411-24. doi: 10.1007/s00253-013-5394-8. Epub 2013 Nov 22.
4
A Precision Microbiome Approach Using Sucrose for Selective Augmentation of Staphylococcus epidermidis Fermentation against Propionibacterium acnes.一种使用蔗糖的精准微生物组方法，用于选择性增强表皮葡萄球菌对痤疮丙酸杆菌的发酵作用。
Int J Mol Sci. 2016 Nov 9;17(11):1870. doi: 10.3390/ijms17111870.
5
Microbiome precision editing: Using PEG as a selective fermentation initiator against methicillin-resistant Staphylococcus aureus.微生物组精准编辑：使用聚乙二醇作为针对耐甲氧西林金黄色葡萄球菌的选择性发酵引发剂。
Biotechnol J. 2017 Apr;12(4). doi: 10.1002/biot.201600399. Epub 2017 Feb 8.
6
Propionic acid and its esterified derivative suppress the growth of methicillin-resistant Staphylococcus aureus USA300.丙酸及其酯化衍生物可抑制耐甲氧西林金黄色葡萄球菌USA300的生长。
Benef Microbes. 2014 Jun 1;5(2):161-8. doi: 10.3920/BM2013.0031.
7
PEG-8 Laurate Fermentation of Reduces the Required Dose of Clindamycin Against .PEG-8 月桂酸酯发酵降低克林霉素对 的所需剂量。
Int J Mol Sci. 2020 Jul 19;21(14):5103. doi: 10.3390/ijms21145103.
8
Staphylococcus aureus hijacks a skin commensal to intensify its virulence: immunization targeting β-hemolysin and CAMP factor.金黄色葡萄球菌劫持皮肤共生菌来增强其毒力：针对β-溶血素和 CAMP 因子的免疫接种。
J Invest Dermatol. 2011 Feb;131(2):401-9. doi: 10.1038/jid.2010.319. Epub 2010 Nov 18.
9
Human skin microbiota is a rich source of bacteriocin-producing staphylococci that kill human pathogens.人类皮肤微生物群是产生细菌素的葡萄球菌的丰富来源，这些葡萄球菌可以杀死人类病原体。
FEMS Microbiol Ecol. 2019 Feb 1;95(2). doi: 10.1093/femsec/fiy241.
10
Propionibacterium acnes Abundance Correlates Inversely with Staphylococcus aureus: Data from Atopic Dermatitis Skin Microbiome.痤疮丙酸杆菌丰度与金黄色葡萄球菌呈负相关：特应性皮炎皮肤微生物组数据。
Acta Derm Venereol. 2018 Apr 27;98(5):490-495. doi: 10.2340/00015555-2896.

引用本文的文献

1
Lichen Simplex Chronicus: Clinical Perspectives and Emerging Therapeutic Strategies.慢性单纯性苔藓：临床观点与新兴治疗策略
Am J Clin Dermatol. 2025 Aug 25. doi: 10.1007/s40257-025-00979-z.
2
Inflammation biomarkers mediate causal inference of the effect of skin microbiota on the risk of allergic diseases.炎症生物标志物介导了皮肤微生物群对过敏性疾病风险影响的因果推断。
AMB Express. 2025 Aug 12;15(1):116. doi: 10.1186/s13568-025-01924-3.
3
The Role of in the Etiopathogenesis of Sarcoidosis: Current Insights and Future Study Directions.

本文引用的文献

1
An expanded multilocus sequence typing scheme for propionibacterium acnes: investigation of 'pathogenic', 'commensal' and antibiotic resistant strains.痤疮丙酸杆菌的扩展多位点序列分型方案：对“致病性”、“共生性”和抗生素耐药菌株的研究。
PLoS One. 2012;7(7):e41480. doi: 10.1371/journal.pone.0041480. Epub 2012 Jul 30.
2
Batch- and continuous propionic acid production from glycerol using free and immobilized cells of Propionibacterium acidipropionici.用游离和固定化的丙酸丙酸杆菌细胞从甘油批量和连续生产丙酸。
Bioresour Technol. 2012 Aug;118:553-62. doi: 10.1016/j.biortech.2012.05.079. Epub 2012 May 24.
3
Regulation of inflammation by short chain fatty acids.
[具体物质]在结节病病因发病机制中的作用：当前见解与未来研究方向
Int J Mol Sci. 2025 Jul 11;26(14):6652. doi: 10.3390/ijms26146652.
4
The Role of Microbiota in the Pathogenesis of Bullous Pemphigoid and Pemphigus Vulgaris: Evidence, Controversies, and Perspectives.微生物群在大疱性类天疱疮和寻常型天疱疮发病机制中的作用：证据、争议与展望
Int J Mol Sci. 2025 Jun 24;26(13):6076. doi: 10.3390/ijms26136076.
5
The Role of Targeted Microbiota Therapy in the Prevention and Management of Puerperal Mastitis.靶向微生物群疗法在产褥期乳腺炎预防与管理中的作用
Diseases. 2025 Jun 5;13(6):176. doi: 10.3390/diseases13060176.
6
Decoding the skin microbiota: A Mendelian randomization study reveals new insights into acne causality.解码皮肤微生物群：一项孟德尔随机化研究揭示了痤疮病因的新见解。
Medicine (Baltimore). 2025 Jun 13;104(24):e42865. doi: 10.1097/MD.0000000000042865.
7
Skin-associated commensal microorganisms and their metabolites.皮肤共生微生物及其代谢产物。
J Appl Microbiol. 2025 May 2;136(5). doi: 10.1093/jambio/lxaf111.
8
Cutaneous T cell immunity.皮肤T细胞免疫
Nat Immunol. 2025 May 7. doi: 10.1038/s41590-025-02145-3.
9
Human Milk Microbiome from Polish Women Giving Birth via Vaginal Delivery-Pilot Study.波兰经阴道分娩女性的母乳微生物群——初步研究
Biology (Basel). 2025 Mar 25;14(4):332. doi: 10.3390/biology14040332.
10
Antioxidant Activities of the Cell-Free Supernatant of a Potential Probiotic Cutibacterium acnes Strain CCSM0331, Isolated From a Healthy Skin.从健康皮肤分离出的潜在益生菌痤疮丙酸杆菌菌株CCSM0331的无细胞上清液的抗氧化活性
J Cosmet Dermatol. 2025 Mar;24(3):e70105. doi: 10.1111/jocd.70105.
短链脂肪酸对炎症的调节作用。
Nutrients. 2011 Oct;3(10):858-76. doi: 10.3390/nu3100858. Epub 2011 Oct 14.
4
Microbial symbiosis with the innate immune defense system of the skin.皮肤的先天免疫防御系统与微生物共生。
J Invest Dermatol. 2011 Oct;131(10):1974-80. doi: 10.1038/jid.2011.182. Epub 2011 Jun 23.
5
Free fatty acid receptors FFAR1 and GPR120 as novel therapeutic targets for metabolic disorders.游离脂肪酸受体 FFAR1 和 GPR120 作为代谢紊乱的新型治疗靶点。
J Pharm Sci. 2011 Sep;100(9):3594-601. doi: 10.1002/jps.22639. Epub 2011 May 25.
6
A descriptive study of bacterial load of full-thickness surgical wounds in dermatologic surgery.一项关于皮肤科手术全层手术伤口细菌负荷的描述性研究。
Dermatol Surg. 2011 Jul;37(7):1014-22. doi: 10.1111/j.1524-4725.2011.02040.x. Epub 2011 May 25.
7
A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation.GPR40 激动剂 GW9508 抑制角质形成细胞中 CCL5、CCL17 和 CXCL10 的诱导，并减轻皮肤免疫炎症。
J Invest Dermatol. 2011 Aug;131(8):1660-7. doi: 10.1038/jid.2011.123. Epub 2011 May 19.
8
The skin microbiome.皮肤微生物组。
Nat Rev Microbiol. 2011 Apr;9(4):244-53. doi: 10.1038/nrmicro2537.
9
Glycerol enhances the antifungal activity of dairy propionibacteria.甘油可增强乳制品丙酸杆菌的抗真菌活性。
Int J Microbiol. 2010;2010:430873. doi: 10.1155/2010/430873. Epub 2011 Jan 20.
10
Propionibacterium acnes vaccination induces regulatory T cells and Th1 immune responses and improves mouse atopic dermatitis.痤疮丙酸杆菌疫苗接种可诱导调节性 T 细胞和 Th1 免疫应答，并改善小鼠特应性皮炎。
Exp Dermatol. 2011 Feb;20(2):157-8. doi: 10.1111/j.1600-0625.2010.01180.x.