Pyo Jeung Hui, Kim Eun Sun, Chun Hoon Jai, Keum Bora, Jeen Yoon Tae, Lee Hong Sik, Kim Chang Duck, Ryu Ho Sang, Kim Young Ha, Lee Jung Eun
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Institute of Digestive Disease and Nutrition, Korea University College of Medicine, Seoul 136-705, Korea.
Clin Nutr Res. 2013 Jan;2(1):34-41. doi: 10.7762/cnr.2013.2.1.34. Epub 2013 Jan 29.
In several previously reported studies, metabolic syndrome (MS) was found to be associated with colorectal adenomas. While the incidence of colorectal adenoma is growing in Korean population, there are only few studies that examined the association between MS and colorectal adenoma in Korea. The aim of this study was to investigate relationships between prevalence of colorectal adenoma and MS components. We conducted a cross sectional study using data from individuals who had undergone complete colonoscopy for health examinations at the Health Promotion Center of Korea University Medical Center from July 1, 2004 to July 31, 2010. A total of 7481 subjects (4459 males and 3022 females) were included; 1733 subjects with pathologically proven adenoma were assigned to the case group, and other 5748 subjects were assigned to the non-case group. All the participants underwent colonoscopy and received blood biochemical tests (fasting blood sugar [FBS], insulin, lipid profile, hemoglobin, blood urea nitrogen [BUN], creatinine). Univariate analysis showed that the prevalence of colorectal adenoma was higher in individuals with higher blood pressure, body mass index (BMI), total cholesterol (TC), triglyceride (TG), FBS and lower high-density lipoprotein cholesterols (HDL-C) levels, compared to those with low levels. Multiple logistic regression analysis revealed that high levels of BMI (OR 1.17, 95% CI 1.01-1.34, P trend = 0.01), TG (OR 1.27, 95% CI 1.07-1.51, P trend = 0.006), and FBS (OR 1.19 95% CI 1.01-1.40, P trend = 0.05) were significantly associated with prevalence of colorectal adenoma. Subjects with high levels of BMI, TG and FBS have increased prevalence of developing colorectal adenoma in Korea.
在几项先前报道的研究中，发现代谢综合征（MS）与结直肠腺瘤有关。虽然韩国人群中结直肠腺瘤的发病率在上升，但在韩国，仅有少数研究探讨了MS与结直肠腺瘤之间的关联。本研究的目的是调查结直肠腺瘤患病率与MS各组分之间的关系。我们采用2004年7月1日至2010年7月31日在韩国大学医学中心健康促进中心接受健康检查并进行全结肠镜检查的个体数据进行了一项横断面研究。共纳入7481名受试者（4459名男性和3022名女性）；1733名经病理证实为腺瘤的受试者被分配到病例组，另外5748名受试者被分配到非病例组。所有参与者均接受了结肠镜检查并进行了血液生化检测（空腹血糖[FBS]、胰岛素、血脂谱、血红蛋白、血尿素氮[BUN]、肌酐）。单因素分析显示，与水平较低者相比，血压、体重指数（BMI）、总胆固醇（TC）、甘油三酯（TG）、FBS水平较高且高密度脂蛋白胆固醇（HDL-C）水平较低的个体中结直肠腺瘤的患病率更高。多因素逻辑回归分析显示，BMI高水平（比值比[OR]1.17，95%可信区间[CI]1.01 - 1.34，P趋势 = 0.01）、TG高水平（OR 1.27，95%CI 1.07 - 1.51，P趋势 = 0.006）和FBS高水平（OR 1.19，95%CI 1.01 - 1.40，P趋势 = 0.05）与结直肠腺瘤患病率显著相关。在韩国，BMI、TG和FBS水平较高的受试者患结直肠腺瘤的患病率增加。
