Cetin E O, Yesil-Celiktas O, Cavusoglu T, Demirel-Sezer E, Akdemir O, Uyanikgil Y
Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Bornova - Izmir, Turkey.
Pharmazie. 2013 Jan;68(1):75-80.
The present study was designed to identify and compare the in vivo wound healing capacity of a bark extract from Pinus brutia and Pycnogenol in an incision wound model in rats. O/W cream formulations were prepared incorporating 2% Pycnogenol and P. brutia bark extract. The rats were divided into three groups (n = 8). Subsequently placebo and test formulations were applied to animals once a day from day "0" until the 9th day. Malondialdehyde (MDA), superoxide dismutase (SOD) and catalase (CAT) were studied in addition to histopathological examinations. Treatment with F. brutia extract containing cream inhibited lipid peroxidation by a 35% decrease in MDA and 46.8% increase in SOD activity, whereas 19.3% decrease in MDA and 34.7% increase in SOD activity were attained with Pynogenol compared to control. The histological data revealed a better performance of P. brutia extract enriched formulation in terms of degeneration of hair roots, increased vascularization and a decrease in necrotic area. Consequently, a high wound healing activity was observed in animals treated with P. brutia extract significantly accelerating the wound healing process.
本研究旨在识别和比较土耳其松树皮提取物和碧萝芷在大鼠切口伤口模型中的体内伤口愈合能力。制备了含有2%碧萝芷和土耳其松树皮提取物的水包油乳膏制剂。将大鼠分为三组（n = 8）。随后，从第“0”天到第9天，每天给动物涂抹一次安慰剂和测试制剂。除了组织病理学检查外，还研究了丙二醛（MDA）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）。用含土耳其松树皮提取物的乳膏治疗可抑制脂质过氧化，MDA降低35%，SOD活性增加46.8%，而与对照组相比，碧萝芷使MDA降低19.3%，SOD活性增加34.7%。组织学数据显示，富含土耳其松树皮提取物的制剂在发根退化、血管生成增加和坏死面积减少方面表现更好。因此，在用土耳其松树皮提取物治疗的动物中观察到高伤口愈合活性，显著加速了伤口愈合过程。
