Tellechea Ana, Kafanas Antonios, Leal Ermelindo C, Tecilazich Francesco, Kuchibhotla Sarada, Auster Michael E, Kontoes Iraklis, Paolino Jacqueline, Carvalho Eugenia, Nabzdyk Leena Pradhan, Veves Aristidis
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Int J Low Extrem Wounds. 2013 Mar;12(1):4-11. doi: 10.1177/1534734612474303. Epub 2013 Feb 26.
Systemic inflammation is associated with impaired wound healing in diabetes mellitus (DM) patients. Using immunohistochemistry techniques, the authors investigated changes in skin inflammation and skin blood vessels in human and experimental diabetes. Comparing to the non-DM human subjects, the total number of inflammatory cells per biopsy and the number of inflammatory cells around blood vessels, a strong indication of inflammation, were higher in DM subjects irrespective of their risk for developing diabetic foot ulcer. Inflammatory cell infiltration was robustly increased in all DM animal models compared with their non-DM controls. The number and density of blood vessels and CD31 positive proliferating endothelial cells around preexisting skin vessels was also higher in the DM patients. However, there were no differences in the skin blood flow between the non-DM and DM subjects. The number of skin blood vessels was also increased in the DM animals; however, these differences were less obvious than the ones observed for inflammatory cells. We conclude that skin inflammation and skin blood vessel density is increased in diabetic human subjects and in rodent and rabbit models of diabetes.
全身炎症与糖尿病（DM）患者伤口愈合受损有关。作者使用免疫组织化学技术，研究了人类和实验性糖尿病中皮肤炎症和皮肤血管的变化。与非糖尿病人类受试者相比，无论糖尿病足溃疡发生风险如何，糖尿病受试者每块活检组织中的炎症细胞总数以及血管周围炎症细胞数量（炎症的有力指标）均更高。与非糖尿病对照相比，所有糖尿病动物模型中的炎症细胞浸润均显著增加。糖尿病患者中，既有皮肤血管周围的血管数量、密度以及CD31阳性增殖内皮细胞数量也更高。然而，非糖尿病和糖尿病受试者之间的皮肤血流量没有差异。糖尿病动物的皮肤血管数量也增加了；然而，这些差异不如炎症细胞的差异明显。我们得出结论，糖尿病人类受试者以及糖尿病啮齿动物和兔模型中皮肤炎症和皮肤血管密度均增加。
