正常受试者的扫频源眼前节光学相干断层扫描测量角膜厚度和体积。

Corneal thickness and volume measurements by swept source anterior segment optical coherence tomography in normal subjects.

机构信息

Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan.

出版信息

Curr Eye Res. 2013 May;38(5):531-6. doi: 10.3109/02713683.2012.745878. Epub 2013 Feb 28.

DOI:10.3109/02713683.2012.745878

PMID:23448300

Abstract

PURPOSE

To evaluate central corneal thickness (CCT) and corneal volume (CV) in healthy eyes using swept source anterior segment optical coherence tomography (SS-AS-OCT) and other devices.

METHODS

Thirty-three healthy right eyes of 33 subjects were investigated. CCT was measured with SS-AS-OCT, rotating Scheimpflug camera, ultrasonic pachymetry and specular microscopy. CV was determined within a diameter of 10 mm at the center using SS-AS-OCT and Scheimpflug camera.

RESULTS

Mean CCT was 523.5 ± 25.2 μm by SS-AS-OCT, 523.9 ± 26.1 μm by Scheimpflug camera, 532.1 ± 26.6 μm by ultrasonic pachymetry, and 525.5 ± 33.5 μm by specular microscopy. The CCTs measured with SS-AS-OCT, Scheimpflug camera and specular microscopy were significantly thinner than those measured with ultrasonic pachymeter (p < 0.001). The mean CV within a diameter of 10 mm at the center was 57.2 ± 3.0 mm(3) by SS-AS-OCT and 59.4 ± 2.9 mm(3) by Scheimpflug camera. Scheimpflug measurements of CV were statistically larger than SS-AS-OCT measurements (p = 0.0008). Statistically significant correlation was found between the CCT and CV measurements of each imaging devices (p < 0.0001, r = 0.527, and p < 0.0001, r = 0.749, respectively).

CONCLUSION

SS-AS-OCT enables the measurements of CCT and CV, demonstrating agreement with other devices. CV in addition to CCT measurement may serve as a practical parameter of the corneal endothelial pump function.

摘要

目的

使用扫频源眼前节光学相干断层扫描（SS-AS-OCT）和其他设备评估健康眼睛的中央角膜厚度（CCT）和角膜体积（CV）。

方法

对 33 名受试者的 33 只右眼进行了研究。使用 SS-AS-OCT、旋转式 Scheimpflug 相机、超声角膜测厚仪和共焦显微镜测量 CCT。使用 SS-AS-OCT 和 Scheimpflug 相机在中心直径 10mm 范围内确定 CV。

结果

SS-AS-OCT 测量的平均 CCT 为 523.5±25.2μm，Scheimpflug 相机为 523.9±26.1μm，超声角膜测厚仪为 532.1±26.6μm，共焦显微镜为 525.5±33.5μm。SS-AS-OCT、Scheimpflug 相机和共焦显微镜测量的 CCT 明显比超声角膜测厚仪测量的 CCT 薄（p<0.001）。中心直径 10mm 范围内的平均 CV 为 SS-AS-OCT 为 57.2±3.0mm(3)，Scheimpflug 相机为 59.4±2.9mm(3)。Scheimpflug 测量的 CV 明显大于 SS-AS-OCT 测量的 CV（p=0.0008）。各成像设备的 CCT 和 CV 测量值之间存在显著相关性（p<0.0001，r=0.527，p<0.0001，r=0.749）。