Nutrition Program, Federal University of São Paulo, São Paulo, SP, Brasil.
J Nutr Health Aging. 2013 Mar;17(3):206-10. doi: 10.1007/s12603-012-0400-x.
The aim of this study is to evaluate the contribution of central obesity to inflammatory responses in the postprandial state in elderly patients with and without metabolic syndrome (MetS).
MATERIAL/METHODS: We evaluated 80 elderly individuals who were distributed into three groups: MetS, abdominal obesity (AbObes) and Control, according to ATPIII criteria. Interleukin-6 (IL-6) serum concentration was measured at 0, 2, 4 and 6 hours after the ingestion of a physiological meal without an overload of fat.
Serum IL-6 increased 6 hours after the meal in all of the groups (P<0.001). Comparing the groups, there was no difference in the area under the curve (AUC) of IL-6 in the postprandial state. There was a correlation between the 6-hour changes in the concentrations of IL-6 and the homeostasis model assessment of insulin resistance (HOMA-IR) (r = 0.25, P<0.05).
In this study, differences in abdominal circumference (AC) have not determined a different behavior of IL-6 in the postprandial state, despite the correlation between AC and IL-6. However, we found that, in the elderly, there is a rise in serum IL-6 at 6 hours.
本研究旨在评估中心性肥胖对伴有和不伴有代谢综合征（MetS）的老年患者餐后炎症反应的影响。
材料/方法：我们评估了 80 名老年人，根据 ATPIII 标准将其分为三组：MetS、腹部肥胖（AbObes）和对照组。在摄入不含脂肪负荷的生理餐后 0、2、4 和 6 小时测量血清白细胞介素-6（IL-6）浓度。
所有组在餐后 6 小时血清 IL-6 均升高（P<0.001）。组间比较，餐后 IL-6 的曲线下面积（AUC）无差异。6 小时内 IL-6 浓度的变化与稳态模型评估的胰岛素抵抗（HOMA-IR）之间存在相关性（r = 0.25，P<0.05）。
在这项研究中，尽管腹部周长（AC）与 IL-6 之间存在相关性，但 AC 的差异并没有决定 IL-6 在餐后状态下的不同行为。然而，我们发现，在老年人中，血清 IL-6 在 6 小时后会升高。
