Department of Food Science and Human Nutrition, University of Maine, Orono, ME 04469, USA.
J Nutr Biochem. 2013 Aug;24(8):1508-12. doi: 10.1016/j.jnutbio.2012.12.010. Epub 2013 Mar 1.
The metabolic syndrome (MetS) is a major public health problem in the United States. Chronic inflammation is a critical component of the MetS, leading to dramatically increased risk of type II diabetes and cardiovascular disease. This study investigates the ability of a wild-blueberry-enriched diet to improve the proinflammatory status associated with MetS in the obese Zucker rat (OZR). Circulating levels of key inflammatory markers and their expression in the liver and abdominal adipose tissue were examined in OZR and its genetic control, the lean Zucker rat (LZR), after feeding a control or an 8% wild blueberry diet (WB) for 8 weeks from age 8 to 16 weeks. In the OZR, WB consumption resulted in decreased plasma concentrations of tumor necrosis factor (TNF)-α (-25.6%, P<.05), interleukin (IL)-6 (-14.9%, P<.05) and C-reactive protein (CRP) (-13.1%, P<.05) and increased adiponectin concentration (+21.8%, P<.05). Furthermore, expression of IL-6, TNF-α and nuclear factor (NF)-kB was down-regulated in both the liver (-65%, -59% and -25%, respectively) and the abdominal adipose tissue (-64%, -52% and -65%), while CRP expression was down-regulated only in the liver (-25%). In the abdominal adipose tissue, similar trends were also observed in LZR following WB treatment, with decreased liver expression of NF-kB, CRP, IL-6 and TNF-α (-24%, -16%, -21% and -50%) and increased adiponectin expression (+25%). Results of this study suggest that wild blueberry consumption exerts an overall anti-inflammatory effect in the OZR, a model of the metabolic syndrome.
代谢综合征（MetS）是美国的一个主要公共卫生问题。慢性炎症是 MetS 的一个关键组成部分，导致 II 型糖尿病和心血管疾病的风险显著增加。本研究调查了富含蓝莓的饮食在肥胖 Zucker 大鼠（OZR）中改善与 MetS 相关的促炎状态的能力。在 8 至 16 周龄时，用对照饮食或 8%野生蓝莓饮食（WB）喂养 8 周后，检查了 OZR 及其遗传对照瘦 Zucker 大鼠（LZR）的循环中关键炎症标志物的水平及其在肝脏和腹部脂肪组织中的表达。在 OZR 中，WB 消耗导致肿瘤坏死因子（TNF）-α（-25.6%，P<.05）、白细胞介素（IL）-6（-14.9%，P<.05）和 C 反应蛋白（CRP）（-13.1%，P<.05）的血浆浓度降低，脂联素浓度增加（+21.8%，P<.05）。此外，在肝脏（分别为-65%、-59%和-25%）和腹部脂肪组织（-64%、-52%和-65%）中，IL-6、TNF-α 和核因子（NF）-kB 的表达均下调，而 CRP 的表达仅在肝脏中下调（-25%）。在腹部脂肪组织中，LZR 在用 WB 处理后也观察到类似的趋势，肝脏中 NF-kB、CRP、IL-6 和 TNF-α 的表达下调（-24%、-16%、-21%和-50%），脂联素的表达上调（+25%）。本研究的结果表明，野生蓝莓的消耗对 OZR 代谢综合征模型具有整体抗炎作用。
