意大利中部慢性乙肝患者的乙肝病毒脱氧核糖核酸、e抗原/e抗体血清学状态
HBV-DNA, HBeAg/anti-HBe serological status in hepatitis B chronic individuals from central Italy.
作者信息
Rapicetta M, di Nardo V, Rozera C, Marinucci G, Francisci D, Sarrecchia B, Ricci C, Albertoni F
机构信息
Department of Virology, Istituto Superiore di Sanità, Rome, Italy.
出版信息
Epidemiol Infect. 1990 Jun;104(3):511-7. doi: 10.1017/s0950268800047518.
A population of 488 HBsAg carrier individuals, from central Italy, classified on the basis of biochemical, clinical and histological parameters, was analysed for the presence of HBV-DNA in serum and its relationship with HBeAg/anti-HBe markers. The prevalence of HBV-DNA was 32.8% in chronic patients with biopsy-proven liver disease, and 20 and 4.3% respectively in asymptomatic carriers with and without altered ALT levels. The values in chronic patients were correlated with the histological activity. Concordance of HBV-DNA presence and HBeAg positivity was observed in only 61.4% of cases. However HBV-DNA prevalence in sera of anti-HBe positive individuals was very low in asymptomatic carriers with normal ALT levels (2.5%). Higher values were observed in anti-HBe positive chronic patients (15.8%) and in carriers occasionally found with changes in ALT without any other clinical sign of illness (16.7%). These data would indicate that HBV-DNA is the serological marker which is most closely related to liver disease.
对来自意大利中部的488名乙肝表面抗原（HBsAg）携带者进行了研究，这些携带者根据生化、临床和组织学参数进行分类，分析了血清中乙肝病毒脱氧核糖核酸（HBV-DNA）的存在情况及其与乙肝e抗原（HBeAg）/乙肝e抗体（anti-HBe）标志物的关系。在经活检证实患有肝病的慢性患者中，HBV-DNA的流行率为32.8%，在谷丙转氨酶（ALT）水平正常和异常的无症状携带者中，该流行率分别为20%和4.3%。慢性患者中的这些值与组织学活性相关。仅在61.4%的病例中观察到HBV-DNA存在与HBeAg阳性的一致性。然而，在ALT水平正常的无症状携带者中，anti-HBe阳性个体血清中的HBV-DNA流行率非常低（2.5%）。在anti-HBe阳性的慢性患者中（15.8%）以及偶尔发现ALT有变化但无任何其他疾病临床症状的携带者中（16.7%），观察到较高的值。这些数据表明，HBV-DNA是与肝病关系最为密切的血清学标志物。
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