Saadah Omar I, Al-Mughales Jamil A
Division of Pediatric Gastroenterology, Department of Pediatrics, Faculty of Medicine, King Abdulaziz University, PO Box 80215, Jeddah 21589, Saudi Arabia.
Clin Dev Immunol. 2013;2013:196012. doi: 10.1155/2013/196012. Epub 2013 Feb 14.
It is unusual for the antineutrophil cytoplasmic antibody with cytoplasmic pattern (cANCA) to present in patients with inflammatory bowel disease (IBD) without vasculitis. The purpose of this study was to describe the occurrence and characteristics of pediatrics IBD with cANCA.
A retrospective review of pediatric IBD associated with cANCA serology in patients from King Abdulaziz University Hospital, Saudi Arabia, between September 2002 and February 2012.
Out of 131 patients with IBD screened for cANCAs, cANCA was positive in 7 (5.3%) patients of whom 4 had ulcerative colitis and 3 had Crohn's disease. The median age was 8.8 years (2-14.8 years). Six (86%) were males. Of the 7 patients, 5 (71%) were Saudi Arabians and 2 were of Indian ethnicity. The most common symptoms were diarrhea, abdominal pain, weight loss, and rectal bleeding. None had family history or clinical features suggestive of vasculitis involving renal and respiratory systems. No difference in the disease location or severity was observed between cANCA positive and cANCA negative patients apart from male preponderance in cANCA positive patients.
The occurrence of cANCA in pediatric IBD is rare. Apart from male preponderance, there were no peculiar characteristics for the cANCA positive patients.
抗中性粒细胞胞浆抗体胞浆型（cANCA）出现在无血管炎的炎症性肠病（IBD）患者中较为罕见。本研究的目的是描述小儿cANCA相关性IBD的发生情况及特征。
对2002年9月至2012年2月期间沙特阿拉伯阿卜杜勒阿齐兹国王大学医院的小儿cANCA血清学相关IBD患者进行回顾性研究。
在131例接受cANCA筛查的IBD患者中，7例（5.3%）cANCA呈阳性，其中4例为溃疡性结肠炎，3例为克罗恩病。中位年龄为8.8岁（2 - 14.8岁）。6例（86%）为男性。7例患者中，5例（71%）为沙特阿拉伯人，2例为印度裔。最常见的症状为腹泻、腹痛、体重减轻和直肠出血。无人有提示累及肾脏和呼吸系统血管炎的家族史或临床特征。除cANCA阳性患者中男性占优势外，cANCA阳性和阴性患者在疾病部位或严重程度上未观察到差异。
小儿IBD中cANCA的出现较为罕见。除男性占优势外，cANCA阳性患者无特殊特征。
