Bragazzi Nicola Luigi
School of Public Health, Department of Health Sciences (DISSAL), University of Genoa, Via Pastore 1, 16132 Genoa, Italy.
Mult Scler Int. 2013;2013:972471. doi: 10.1155/2013/972471. Epub 2013 Feb 14.
Multiple sclerosis (MS) is a chronic neurological disease whose etiology has not been fully understood yet in detail. Empirical findings show how psychosocial symptoms are very important features of the clinical presentation of MS, having a deep impact on patient's quality of life, and thus psychological coping strategies may play a central role in reducing the burden of the disease and improving patient's satisfaction of life. MS progression and relapses/exacerbations are unpredictable and may depend on factors such as stressor chronicity, frequency, severity, type, and individual patient characteristics such as depression, personality, locus of control (LOC), optimism, and perceived social support. Due to its importance for health-care delivery, rehabilitation, and nursing, here, we make a systematic review on the current state-of-the-art studies concerning the relationship between LOC and MS, according to the PRISMA guidelines, and we assess the quality and the completeness of the studies using the CONSORT instrument, underpinning their limitations, and suggesting how to fill the gap in this research field.
多发性硬化症（MS）是一种慢性神经疾病，其病因尚未得到充分详细的了解。实证研究结果表明，心理社会症状是MS临床表现的非常重要的特征，对患者的生活质量有深远影响，因此心理应对策略可能在减轻疾病负担和提高患者生活满意度方面发挥核心作用。MS的进展和复发/加重是不可预测的，可能取决于压力源的慢性程度、频率、严重程度、类型等因素，以及个体患者的特征，如抑郁、性格、控制点（LOC）、乐观主义和感知到的社会支持。由于其对医疗保健、康复和护理的重要性，在此，我们根据PRISMA指南，对当前关于LOC与MS之间关系的最新研究进行系统综述，并使用CONSORT工具评估研究的质量和完整性，强调其局限性，并提出如何填补这一研究领域的空白。
