用于研究锌金属神经化学的螯合剂。
Chelators for investigating zinc metalloneurochemistry.
机构信息
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, United States.
出版信息
Curr Opin Chem Biol. 2013 Apr;17(2):129-36. doi: 10.1016/j.cbpa.2013.01.009. Epub 2013 Mar 13.
Abstract
The physiology and pathology of mobile zinc signaling has become an important topic in metalloneurochemistry. To study the action of mobile zinc effectively, specialized tools are required that probe the temporal and positional changes of zinc ions within live tissue and cells. In the present article we describe the design and implementation of selective zinc chelators as antagonists to interrogate the function of mobile zinc, with an emphasis on the pools of vesicular zinc in the terminals of hippocampal mossy fiber buttons.
摘要
移动锌信号的生理学和病理学已成为金属神经化学的一个重要课题。为了有效地研究移动锌的作用，需要专门的工具来探测活体组织和细胞内锌离子的时间和位置变化。本文描述了选择性锌螯合剂的设计和实施，作为拮抗物来探究移动锌的功能，重点是海马苔藓纤维末梢囊泡锌的池。
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