18FDG PET-CT 用于食管癌淋巴结分期的荟萃分析。
Meta-analysis of 18FDG PET-CT for nodal staging in patients with esophageal cancer.
机构信息
Department of Cardio-Thoracic Surgery, the third People's hospital, Yancheng, 224001, China.
出版信息
Surg Oncol. 2013 Jun;22(2):112-6. doi: 10.1016/j.suronc.2013.02.003. Epub 2013 Mar 7.
BACKGROUND
We aimed to evaluate the value of (18)FDG PET-CT for detection of regional nodal metastasis in patients with esophageal cancer before surgery.
METHODS
A computer search about PET-CT original articles was conducted from January 2000 to December 2012. The reference standard was histopathologic analysis. Two reviewers independently searched articles and extracted data. Sensitivity, specificity, diagnostic odds ratio, and likelihood ratio were pooled for PET-CT using bivariate models. Summary receiver operating characteristic (SROC) curves were also used to summarize overall test performance.
RESULTS
Across all seven studies on a per-station analysis (2232 stations), the pooled sensitivity and specificity with 95% confidence interval for PET-CT were 0.62 (0.40-0.79) and 0.96 (0.93-0.98). Across all 6 studies on a per-patient analysis (245 patients), corresponding values for PET-CT were 0.55 (0.34-0.74) and 0.76 (0.66-0.83).
CONCLUSIONS
(18)FDG PET-CT had lower sensitivity and accuracy for detection of regional nodal metastasis in patients with esophageal cancer before surgery.
背景
我们旨在评估（18）FDG PET-CT 在术前检测食管癌患者区域淋巴结转移中的价值。
方法
从 2000 年 1 月至 2012 年 12 月，我们对 PET-CT 原始文献进行了计算机检索。参考标准是组织病理学分析。两位评审员独立搜索文章并提取数据。使用双变量模型对 PET-CT 进行汇总敏感性、特异性、诊断优势比和似然比。还使用综合受试者工作特征（SROC）曲线来总结整体试验性能。
结果
在所有 7 项基于站点的分析研究（2232 个站点）中，PET-CT 的汇总敏感性和特异性及其 95%置信区间为 0.62（0.40-0.79）和 0.96（0.93-0.98）。在所有 6 项基于患者的分析研究（245 例患者）中，PET-CT 的相应值为 0.55（0.34-0.74）和 0.76（0.66-0.83）。
结论
（18）FDG PET-CT 对术前检测食管癌患者区域淋巴结转移的敏感性和准确性较低。
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