抗肿瘤药物，103. 从东非轮生叶假杜鹃中分离出低雌激素素1和2及其结构

Antineoplastic agents, 103. The isolation and structure of hypoestestatins 1 and 2 from the East African Hypoëstes verticillaris.

作者信息

Pettit G R, Goswami A, Cragg G M, Schmidt J M, Zou J C

出版信息

J Nat Prod. 1984 Nov-Dec;47(6):913-9. doi: 10.1021/np50036a001.

Abstract

The East African shrub Hypoëstes verticillaris representing a heretofore chemically unexplored. Acanthaceae genus has been found to contain two new cell growth inhibitory (murine P-388 lymphocytic leukemia) phenanthroindolizidine alkaloids termed hypoestestatin 1 (1a) and hypoestestatin 2 (1b). Both substances were found to markedly inhibit growth of the murine P-388 cell line (ED50 = 10(-5) micrograms/ml). The structures of hypoestestatins 1 and 2 were assigned primarily on the basis of results from extensive spectral studies.

摘要

东非灌木轮生叶九头狮子草（Hypoëstes verticillaris），代表了一个迄今为止化学上未被探索的爵床科属。现已发现其含有两种新的具有细胞生长抑制活性（针对小鼠P-388淋巴细胞白血病）的菲并吲哚里西啶生物碱，分别命名为九头狮子草素1（1a）和九头狮子草素2（1b）。发现这两种物质均能显著抑制小鼠P-388细胞系的生长（半数有效剂量=10^(-5)微克/毫升）。九头狮子草素1和2的结构主要是根据广泛的光谱研究结果确定的。