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辛伐他汀与人乳磨牙氢氧化钙直接盖髓术的比较：一项随机临床试验。

Simvastatin versus Calcium Hydroxide Direct Pulp Capping of Human Primary Molars: A Randomized Clinical Trial.

作者信息

Asl Aminabadi Naser, Maljaei Ensiyeh, Erfanparast Leila, Ala Aghbali Amir, Hamishehkar Hamed, Najafpour Ebrahim

机构信息

Dntal and Periodontal Research Center, Tabriz University of Medical Sciences, Tabriz, Iran ; Professor, Department of Pediatric Dentistry, Faculty of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

出版信息

J Dent Res Dent Clin Dent Prospects. 2013 Winter;7(1):8-14. doi: 10.5681/joddd.2013.002. Epub 2013 Feb 21.

DOI:10.5681/joddd.2013.002
PMID:23487477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3593207/
Abstract

BACKGROUND AND AIMS

The aim of present study was to investigate pulp-dentin complex reactions following direct pulp capping (DPC) with calcium hydroxide [Ca(OH)2] and simvastatin as pulp-capping materials in the primary human molars.

MATERIALS AND METHODS

120 primary molar teeth which had to be extracted for orthodontic reasons were randomly allocated into four groups. Group Ι as a control, underwent DPC with calcium hydroxide. The dental pulp in group ІІ, ІІІ and ІV were directly capped with simvastatin-based materials at concentrations of 1, 5 and 10 µM, respectively. All of the teeth were restored with stainless steel crown. After a mean period of 7.41 months teeth were extracted and processed for histological examination and categorized in terms of hard tissue formation and pulp inflammation.

RESULTS

Teeth in group I had statistically favorable outcomes in hard tissue formation and pulp inflammation than did the groups ІІ, ІІІ and ІV (P < 0.001). Considering three different concentrations of simvastatin, the result showed a dose dependent trend. Teeth in group ІV showed significantly lower rates of hard tissue formation and higher rates of pulp inflammation and necrosis compared to those of groups ІІ (P < 0.05).

CONCLUSION

The findings of this study depicted that healing with no inflammation and hard tissue formation following statin treatment occurs with a lower rate than that with the calcium hydroxide.

摘要

背景与目的

本研究旨在调查以氢氧化钙[Ca(OH)₂]和辛伐他汀作为盖髓材料对人乳牙进行直接盖髓（DPC）后牙髓-牙本质复合体的反应。

材料与方法

120颗因正畸原因需要拔除的乳牙随机分为四组。第一组作为对照组，用氢氧化钙进行直接盖髓。第二、三、四组的牙髓分别用浓度为1、5和10µM的辛伐他汀基材料直接盖髓。所有牙齿均用不锈钢冠修复。平均7.41个月后拔除牙齿并进行组织学检查，根据硬组织形成和牙髓炎症进行分类。

结果

第一组牙齿在硬组织形成和牙髓炎症方面的统计学结果优于第二、三、四组（P < 0.001））。考虑到三种不同浓度的辛伐他汀，结果显示出剂量依赖性趋势。与第二组相比，第四组牙齿的硬组织形成率显著降低，牙髓炎症和坏死率更高（P < 0.05）。

结论

本研究结果表明，他汀类药物治疗后无炎症且有硬组织形成的愈合发生率低于氢氧化钙治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/150e/3593207/6625d202a16a/joddd-7-8-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/150e/3593207/5aeef2639de3/joddd-7-8-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/150e/3593207/5ad74a8f52bb/joddd-7-8-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/150e/3593207/aef4f7978db4/joddd-7-8-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/150e/3593207/6625d202a16a/joddd-7-8-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/150e/3593207/5aeef2639de3/joddd-7-8-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/150e/3593207/5ad74a8f52bb/joddd-7-8-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/150e/3593207/aef4f7978db4/joddd-7-8-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/150e/3593207/6625d202a16a/joddd-7-8-g004.jpg

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