Cancer Council Victoria, 100 Drummond Street, Carlton, VIC 3053, Australia.
Nicotine Tob Res. 2013 Sep;15(9):1578-87. doi: 10.1093/ntr/ntt025. Epub 2013 Mar 14.
Most smokers have a history of unsuccessful quit attempts. This study used data from 7 waves (2002-2009) of the International Tobacco Control 4-country cohort study to examine the role of smokers' quitting history (e.g., recency, length, and number of previous quit attempts) on their subsequent likelihood of making a quit attempt and achieving at least 6 months of sustained abstinence.
Generalized estimating equations were used, allowing for estimation of relationships between variables across repeated observations while controlling for correlations from multiple responses by the same individual (29,682 observations from 13,417 individuals).
The likelihood of a future quit attempt increased independently with recency and number of prior attempts. By contrast, the likelihood of achieving sustained abstinence of at least 6 months was reduced for smokers with a failed quit attempt within the last year (15.1% vs. 27.1% for those without, p < .001). Two or more failed attempts (vs. only one) in the previous year were also associated with a lower likelihood of achieving sustained abstinence (OR: 0.57, 95% CI: 0.38-0.85). Effects persisted after controlling for levels of addiction, self-efficacy to quit, and use of stop-smoking medications.
There appears to be a subset of smokers who repeatedly attempt but fail to remain abstinent from tobacco. Understanding why repeated attempts might be less successful in the long term is an important research priority because it implies a need to tailor treatment approaches for those who are motivated to quit but persistently relapse back to smoking.
大多数吸烟者都有过戒烟失败的经历。本研究利用来自 7 个波次(2002-2009 年)的国际烟草控制 4 国队列研究的数据,考察了吸烟者戒烟史(如最近一次戒烟尝试的时间、持续时间和次数)对其随后尝试戒烟并达到至少 6 个月持续戒烟的可能性的影响。
采用广义估计方程,允许在控制同一人多次回答相关性的同时,对重复观察之间的变量关系进行估计(来自 13417 个人的 29682 次观察)。
未来戒烟尝试的可能性与最近一次戒烟尝试的时间和之前戒烟尝试的次数独立相关。相比之下,在过去一年中戒烟失败的吸烟者实现至少 6 个月持续戒烟的可能性降低(失败组为 15.1%,未失败组为 27.1%,p<0.001)。在过去一年中进行过两次或更多次戒烟尝试(而非仅一次)也与实现持续戒烟的可能性降低相关(OR:0.57,95%CI:0.38-0.85)。在控制成瘾程度、戒烟自我效能感和使用戒烟药物的水平后,这些影响仍然存在。
似乎有一部分吸烟者反复尝试但无法保持烟草戒断。了解为什么长期来看,反复尝试可能不太成功,这是一个重要的研究重点,因为这意味着需要针对那些有戒烟意愿但持续复吸的人量身定制治疗方法。