Tariq Muhammad Usman, Din Nasir Ud, Bashir Muhammad Rizwan
Department of Pathology and Microbiology, Aga Khan University, Stadium Road, Karachi, Pakistan.
Head Neck Pathol. 2013 Sep;7(3):232-5. doi: 10.1007/s12105-013-0433-4. Epub 2013 Mar 15.
Hairy polyps (HPs), dermoids or teratoid tumors are rare tumors of naso-oropharyngeal region which commonly present at or shortly after birth. The etiology and classification of these tumors is still debatable and categorized by different authors differently. HPs have female predominance and usually present with respiratory and feeding problems. Microscopically, the polyp is covered by skin with underlying mesenchymal core. The aim of this study is to describe the clinicopathological features of Hairy polyps on a cohort of cases. We reviewed the surgical pathology database of our institution for last 10 years and retrieved four cases of hairy polyps. The age of patients ranged from 1 month to 18 years (mean = 12 years), with a female to male ratio of 1:3. Two of our cases presented at birth and two cases in late teens. Two of the HPs were located in nasopharynx, one on soft and hard palate and one on lower lip. One case was associated with bifurcation of tongue. Size of the polyps ranged from 2.3 to 4.5 cm (mean = 3 cm). Histologically, all HPs were lined by skin and the underlying core consisted of adnexal structures, adipocytes, skeletal muscle, smooth muscle and seromucinous glands. Lymphoid aggregates, cartilage and bone were seen in one case each. Our series highlights the diverse nature of this entity in terms of age of presentation and location. HP at lower lip and associated bifurcation of tongue has not been previously reported. We observed a male predominance in contrast to the published literature. However, number of cases is too few to read a definite conclusion on this point. The etiology is still controversial and includes congenital malformation and activation of pluripotent stem cells.
毛发状息肉（HPs）、皮样囊肿或畸胎样肿瘤是鼻咽部罕见的肿瘤，通常在出生时或出生后不久出现。这些肿瘤的病因和分类仍存在争议，不同作者有不同的分类方式。毛发状息肉以女性居多，通常表现为呼吸和喂养问题。在显微镜下，息肉表面覆盖有皮肤，其下方为间充质核心。本研究的目的是描述一组毛发状息肉病例的临床病理特征。我们回顾了本机构过去10年的手术病理数据库，检索到4例毛发状息肉病例。患者年龄从1个月至18岁不等（平均12岁），男女比例为1:3。我们的病例中有2例在出生时出现，2例在青少年后期出现。其中2例毛发状息肉位于鼻咽部，1例位于软硬腭，1例位于下唇。1例与舌分叉有关。息肉大小从2.3厘米至4.5厘米不等（平均3厘米）。组织学上，所有毛发状息肉均由皮肤覆盖，其下方核心由附属结构、脂肪细胞、骨骼肌、平滑肌和浆液黏液性腺组成。各有1例可见淋巴滤泡、软骨和骨。我们的系列病例突出了该实体在发病年龄和部位方面的多样性。下唇毛发状息肉及相关舌分叉此前未见报道。与已发表文献相反，我们观察到男性居多。然而，病例数量太少，无法就此得出明确结论。其病因仍存在争议，包括先天性畸形和多能干细胞的激活。
