Shin Dong-Ho, Martinez Sabrina S, Parsons Mary, Jayaweera Dushyantha T, Campa Adriana, Baum Marianna K
Florida International University, Miami FL 33199 USA.
Int J Biosci Biochem Bioinforma. 2012;2(3):217-223. doi: 10.7763/ijbbb.2012.v2.104.
HIV and HCV infections are both characterized by increased oxidative stress. Information on the magnitude of this increase and its consequences in HIV/HCV co-infection and viral replication is limited. We investigated the relationship between oxidative stress and HIV-progression in HIV/HCV co-infected and HIV mono-infected adults.
106 HIV/HCV co-infected and 115 HIV mono-infected participants provided demographic information and blood to determine 8-oxo-dG and percent oxidized glutathione.
HIV/HCV co-infected subjects had higher percent oxidized glutathione, higher HIV viral load, lower mtDNA copies and higher liver fibrosis than mono-infected subjects. In a small sample of HIV/HCV co-infected participants with liver biopsy, 8-oxo-dG was significantly lower in participants with low fibrosis scores than those with high fibrosis scores, and the grade of inflammation was strongly associated with oxidized glutathione.
HIV/HCV co-infection seems to diminish the capacity of the antioxidant system to control oxidative stress, and increases HIV replication.
HIV和HCV感染均以氧化应激增加为特征。关于这种增加的程度及其在HIV/HCV合并感染和病毒复制中的后果的信息有限。我们研究了氧化应激与HIV/HCV合并感染及HIV单感染成年人中HIV进展之间的关系。
106名HIV/HCV合并感染和115名HIV单感染参与者提供了人口统计学信息和血液样本，以测定8-氧代脱氧鸟苷和氧化型谷胱甘肽百分比。
与单感染受试者相比，HIV/HCV合并感染受试者的氧化型谷胱甘肽百分比更高、HIV病毒载量更高、线粒体DNA拷贝数更低且肝纤维化程度更高。在一小部分进行肝活检的HIV/HCV合并感染参与者中，纤维化评分低的参与者的8-氧代脱氧鸟苷明显低于纤维化评分高的参与者，并且炎症程度与氧化型谷胱甘肽密切相关。
HIV/HCV合并感染似乎会削弱抗氧化系统控制氧化应激的能力，并增加HIV复制。
