Department of Medicine, Division of Community Internal Medicine and Clinical Research Office and Center of Science and Health Care Delivery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Department of Health Science Research, Division of Epidemiology and Center of Science and Health Care Delivery, Mayo Clinic, 200 First Street SW, Rochester, MN, 55905, USA.
Lasers Med Sci. 2020 Apr;35(3):663-675. doi: 10.1007/s10103-019-02867-5. Epub 2019 Aug 31.
Obesity and overweight is a global health crisis and novel methods of treatment are needed to address it. Low-level laser therapy (LLLT) is a currently available non-invasive procedure for lysing excess fat, but there is a lack of consensus exists on LLLT frequency and limited research from studies of LLLT. The purpose of this pilot study is to compare the effect of three of the most common LLLT frequencies on weight, waist circumference, body fat percentage, and quality of life. Sixty overweight (body mass index (BMI) 25-29.9 kg/m) adult participants were randomized to 12 LLLT treatments: (1) three times weekly for 4 weeks, (2) twice weekly for 6 weeks, or (3) once weekly for 12 weeks. All participants attended an in-person visit at baseline and at weeks 4, 6, 12, and 26. Participants were recruited September 30, 2016 through to August 27, 2017. The majority of the 60 participants were female (90%) with an average age of 43.7 years (± 9.2 years). Most participants (98%) completed 10 or more of the 12 LLLT treatments. When comparing across treatment groups, the greatest reductions from baseline were observed in those assigned to twice weekly for 6 weeks in weight (1 ± 1.7 (±SD) kg by week 6), waist circumference (- 2.0 ± 3.2 in. by week 6 and - 1.5 ± 3.2 in. by week 26), body mass index (- 0.4 ± 0.6 kg/m), and body fat mass (- 1.1 ± 1.6 kg). This group also had the most significant improvement from baseline in quality of life (+ 0.5 ± 0.8 by week 6), body satisfaction (+ 0.2 ± 0.4 by week 6 and week 26), and body appreciation (+ 0.2 ± 0.3 by week 6 and + 0.3 ± 0.3 by week 26). LLLT twice weekly for 6 weeks could be proposed as the optimal frequency and duration for the management of body weight. Trial registration: https://clinicaltrials.gov/ct2/show/NCT02877004. Registered August 24, 2016.
肥胖和超重是全球健康危机，需要新的治疗方法来解决。低水平激光疗法（LLLT）是一种目前可用的非侵入性程序，用于溶解多余的脂肪，但对于 LLLT 的频率缺乏共识，并且对 LLLT 的研究也有限。本研究旨在比较三种最常见的 LLLT 频率对体重、腰围、体脂百分比和生活质量的影响。
60 名超重（体重指数（BMI）25-29.9kg/m）成年参与者被随机分为 12 种 LLLT 治疗组：（1）每周 3 次，持续 4 周；（2）每周 2 次，持续 6 周；或（3）每周 1 次，持续 12 周。所有参与者在基线和第 4、6、12 和 26 周进行面对面访视。参与者于 2016 年 9 月 30 日至 2017 年 8 月 27 日招募。在 60 名参与者中，大多数为女性（90%），平均年龄为 43.7 岁（±9.2 岁）。大多数参与者（98%）完成了 12 次 LLLT 治疗中的 10 次或更多次。
与治疗组相比，每周 2 次治疗 6 周的患者体重下降最大（第 6 周时 1.0±1.7（±SD）kg），腰围（第 6 周时-2.0±3.2 英寸，第 26 周时-1.5±3.2 英寸），体重指数（-0.4±0.6kg/m）和体脂质量（-1.1±1.6kg）。该组在生活质量（第 6 周时+0.5±0.8）、身体满意度（第 6 周和第 26 周时+0.2±0.4）和身体欣赏（第 6 周和第 26 周时+0.2±0.3）方面的改善也最为显著。
每周 2 次，持续 6 周的 LLLT 治疗可作为体重管理的最佳频率和持续时间。
https://clinicaltrials.gov/ct2/show/NCT02877004。于 2016 年 8 月 24 日注册。
