在康涅狄格州的两个大学项目中，使用自身卵子进行辅助生殖技术（ART）治疗的 43 岁及以上女性的生殖结局。
Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs.
机构信息
Obstetrics, Gynecology and Reproductive Sciences, Yale University Fertility Center, New Haven, CT 06511, USA.
出版信息
J Assist Reprod Genet. 2013 Jun;30(5):673-8. doi: 10.1007/s10815-013-9981-5. Epub 2013 Mar 22.
Abstract
PURPOSE
The aim of this study was to analyze the outcomes of IVF/ICSI cycles in women aged 43 and beyond.
METHODS
Retrospective analysis of clinical pregnancy and live birth rates in 168 fresh, non donor, ART cycles performed in two Connecticut university IVF programs.
RESULTS
In women of 43 and 44 years the overall clinical pregnancy and live birth rates were 8.3% and 5.3% per initiated cycle, respectively. There were no clinical pregnancies in women ≥45 years old. First cycle characteristics were not different from repeated cycles in terms of duration of ovulation induction, number of collected oocytes and transferred embryos (p > 0.05).
CONCLUSIONS
Pregnancies can still be achieved with IVF/ICSI up to the age of 44. Since most pregnancies occurred within the first 3 cycles, another attempt may be a reasonable option before resorting to oocyte donation for patients who failed two previous cycles. Women 45 years and beyond do not benefit from ART procedures using their own oocytes.
摘要
目的
本研究旨在分析 43 岁及以上女性的体外受精/卵胞浆内单精子注射（IVF/ICSI）周期的结局。
方法
回顾性分析了在康涅狄格州两所大学的两个 IVF 项目中进行的 168 例新鲜、非供体、ART 周期的临床妊娠和活产率。
结果
43 岁和 44 岁的女性每个启动周期的总体临床妊娠率和活产率分别为 8.3%和 5.3%。≥45 岁的女性无一例临床妊娠。在排卵诱导持续时间、采集的卵子数量和移植的胚胎数量方面，首次周期特征与重复周期无差异（p>0.05）。
结论
在 44 岁之前，仍然可以通过 IVF/ICSI 实现妊娠。由于大多数妊娠发生在前 3 个周期内，因此对于在前两个周期失败的患者，在寻求卵子捐赠之前，再次尝试可能是合理的选择。45 岁及以上的女性无法从使用自身卵子的 ART 程序中获益。
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