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Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs.在康涅狄格州的两个大学项目中，使用自身卵子进行辅助生殖技术（ART）治疗的 43 岁及以上女性的生殖结局。
J Assist Reprod Genet. 2013 Jun;30(5):673-8. doi: 10.1007/s10815-013-9981-5. Epub 2013 Mar 22.
2
Analysis of IVF/ICSI-FET Outcomes in Women With Advanced Endometriosis: Influence on Ovarian Response and Oocyte Competence.分析患有中重度子宫内膜异位症的妇女行 IVF/ICSI-FET 的结局：对卵巢反应和卵母细胞质量的影响。
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The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age.胞浆内单精子注射在高龄产妇非男性因素不孕中的作用。
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ICSI does not increase the cumulative live birth rate in non-male factor infertility.ICSI 并不会增加非男性因素不孕的累积活产率。
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The number of oocytes associated with maximum cumulative live birth rates per aspiration depends on female age: a population study of 221 221 treatment cycles.与每个抽吸相关的最大累积活产率相关的卵母细胞数量取决于女性年龄：221221 个治疗周期的人群研究。
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In Vitro Fertilisation and Intracytoplasmic Sperm Injection predictive factors: A review of the effect of female age, ovarian reserve, male age, and male factor on IVF/ICSI treatment outcomes.体外受精和胞浆内单精子注射预测因素：女性年龄、卵巢储备、男性年龄和男性因素对 IVF/ICSI 治疗结局影响的综述。
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The Effect of Advanced Maternal Age on Embryo Morphokinetics.高龄产妇对胚胎发育动力学的影响。
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The Effect of Melatonin on Mitochondrial Function and Autophagy in In Vitro Matured Oocytes of Aged Mice.褪黑素对老龄小鼠体外成熟卵母细胞线粒体功能和自噬的影响
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Risk of adverse perinatal outcomes after oocyte donation: a systematic review and meta-analysis.供卵后不良围产结局的风险：系统评价和荟萃分析。
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One thousand seventy-eight autologous IVF cycles in women 45 years and older: the largest single-center cohort to date.1078 个 45 岁及以上女性的自体 IVF 周期：目前为止最大的单一中心队列。
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Predictors of live birth and pregnancy success after fertilization in infertile women aged 40 and over.40岁及以上不孕女性受精后活产及妊娠成功的预测因素。
Clin Exp Reprod Med. 2017 Jun;44(2):111-117. doi: 10.5653/cerm.2017.44.2.111. Epub 2017 Jun 30.

本文引用的文献

1
[Study on the unintended pregnancy among married women of child-bearing age living in Qingshan district, Wuhan].
Zhonghua Liu Xing Bing Xue Za Zhi. 2012 Mar;33(3):291-5.
2
Multiple meiotic errors caused by predivision of chromatids in women of advanced maternal age undergoing in vitro fertilisation.高龄妇女体外受精中染色单体预分裂导致多次减数分裂错误。
Eur J Hum Genet. 2012 Jul;20(7):742-7. doi: 10.1038/ejhg.2011.272. Epub 2012 Feb 8.
3
Insurance coverage and in vitro fertilization outcomes: a U.S. perspective.保险覆盖范围和体外受精结局：美国视角。
Fertil Steril. 2011 Mar 1;95(3):964-9. doi: 10.1016/j.fertnstert.2010.06.030. Epub 2010 Aug 5.
4
Cumulative live-birth rates after in vitro fertilization.体外受精后的累积活产率。
N Engl J Med. 2009 Jan 15;360(3):236-43. doi: 10.1056/NEJMoa0803072.
5
Preimplantation aneuploidy testing for infertile patients of advanced maternal age: a randomized prospective trial.高龄不孕患者植入前非整倍体检测：一项随机前瞻性试验。
Fertil Steril. 2009 Jul;92(1):157-62. doi: 10.1016/j.fertnstert.2008.05.029. Epub 2008 Aug 9.
6
Assisted reproductive technology surveillance--United States, 2005.2005年美国辅助生殖技术监测
MMWR Surveill Summ. 2008 Jun 20;57(5):1-23.
7
Cumulative live birth rates following IVF in 41- to 43-year-old women presenting with favourable ovarian reserve characteristics.41至43岁具有良好卵巢储备特征的女性接受体外受精后的累积活产率。
Reprod Biomed Online. 2007 Apr;14(4):455-63. doi: 10.1016/s1472-6483(10)60893-0.
8
Retrospective analysis of 1217 IVF cycles in women aged 40 years and older.对1217个40岁及以上女性的体外受精周期进行回顾性分析。
Reprod Biomed Online. 2007 Mar;14(3):348-55. doi: 10.1016/s1472-6483(10)60878-4.
9
High rate of biological loss in assisted reproduction: it is in the seed, not in the soil.辅助生殖中生物学损失率高：问题在于种子，而非土壤。
Reprod Biomed Online. 2007 Jan;14(1):92-5. doi: 10.1016/s1472-6483(10)60769-9.
10
Natural conception after age 45 in Bedouin women, a uniquely fertile population.45岁以上贝都因女性自然受孕情况，一个生育率独特的群体。
J Assist Reprod Genet. 2006 Jul-Aug;23(7-8):305-9. doi: 10.1007/s10815-006-9058-9. Epub 2006 Sep 1.

在康涅狄格州的两个大学项目中，使用自身卵子进行辅助生殖技术（ART）治疗的 43 岁及以上女性的生殖结局。

Reproductive outcome of women 43 years and beyond undergoing ART treatment with their own oocytes in two Connecticut university programs.

机构信息

Obstetrics, Gynecology and Reproductive Sciences, Yale University Fertility Center, New Haven, CT 06511, USA.

出版信息

J Assist Reprod Genet. 2013 Jun;30(5):673-8. doi: 10.1007/s10815-013-9981-5. Epub 2013 Mar 22.

DOI:10.1007/s10815-013-9981-5
PMID:23519397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3663975/
Abstract

PURPOSE

The aim of this study was to analyze the outcomes of IVF/ICSI cycles in women aged 43 and beyond.

METHODS

Retrospective analysis of clinical pregnancy and live birth rates in 168 fresh, non donor, ART cycles performed in two Connecticut university IVF programs.

RESULTS

In women of 43 and 44 years the overall clinical pregnancy and live birth rates were 8.3% and 5.3% per initiated cycle, respectively. There were no clinical pregnancies in women ≥45 years old. First cycle characteristics were not different from repeated cycles in terms of duration of ovulation induction, number of collected oocytes and transferred embryos (p > 0.05).

CONCLUSIONS

Pregnancies can still be achieved with IVF/ICSI up to the age of 44. Since most pregnancies occurred within the first 3 cycles, another attempt may be a reasonable option before resorting to oocyte donation for patients who failed two previous cycles. Women 45 years and beyond do not benefit from ART procedures using their own oocytes.

摘要

目的

本研究旨在分析 43 岁及以上女性的体外受精/卵胞浆内单精子注射（IVF/ICSI）周期的结局。

方法

回顾性分析了在康涅狄格州两所大学的两个 IVF 项目中进行的 168 例新鲜、非供体、ART 周期的临床妊娠和活产率。

结果

43 岁和 44 岁的女性每个启动周期的总体临床妊娠率和活产率分别为 8.3%和 5.3%。≥45 岁的女性无一例临床妊娠。在排卵诱导持续时间、采集的卵子数量和移植的胚胎数量方面，首次周期特征与重复周期无差异（p>0.05）。

结论

在 44 岁之前，仍然可以通过 IVF/ICSI 实现妊娠。由于大多数妊娠发生在前 3 个周期内，因此对于在前两个周期失败的患者，在寻求卵子捐赠之前，再次尝试可能是合理的选择。45 岁及以上的女性无法从使用自身卵子的 ART 程序中获益。