Department of Otolaryngology, Medical School, Cumhuriyet University, Sivas, Turkey,
Eur Arch Otorhinolaryngol. 2013 Nov;270(12):3075-8. doi: 10.1007/s00405-013-2439-7. Epub 2013 Mar 22.
Our aim was to evaluate the effects of iatrogenic, acute and deep hypothyroidism on nasal mucociliary clearance. A total of 46 patients undergoing total or near total thyroidectomy for differentiated thyroid cancer between March and June 2012, and scheduled to undergo radioactive iodine (I-131) ablation therapy followed with an induced hypothyroidism for routine screening were included in the study. Mucociliary clearance test was made during hypothyroid and euthyroid periods in all the patients included in the study. Of the 46 patients included in the study, 37 (%80.4) were females, 9 (%19.6) were males, and the average mucociliary clearance times were 16.78 and 9.58 min during hypothyroid and euthyroid periods, respectively. When the results were compared statistically, mucociliary clearance time measured during hypothyroidism period was found to be significantly longer than the one measured during euthyroid period. Mucociliary clearance time was found to be long during iatrogenic acute and deep hypothyroid periods. During these periods, patients should be followed closely for lower and upper respiratory tract infections.
我们的目的是评估医源性、急性和深度甲状腺功能减退症对鼻黏液纤毛清除功能的影响。本研究共纳入 46 例 2012 年 3 月至 6 月期间因分化型甲状腺癌行甲状腺全切除术或近全切除术且计划行放射性碘（I-131）消融治疗后行诱导性甲状腺功能减退症常规筛查的患者。所有纳入研究的患者均在甲状腺功能减退症和甲状腺功能正常期间进行黏液纤毛清除试验。在纳入研究的 46 例患者中，37 例（80.4%）为女性，9 例（19.6%）为男性，甲状腺功能减退症和甲状腺功能正常期间的平均黏液纤毛清除时间分别为 16.78 分钟和 9.58 分钟。统计学比较结果显示，甲状腺功能减退症期间测量的黏液纤毛清除时间明显长于甲状腺功能正常期间。在医源性急性和深度甲状腺功能减退症期间，黏液纤毛清除时间较长。在此期间，应密切关注患者下呼吸道和上呼吸道感染的情况。
