The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.
Science. 2013 Mar 22;339(6126):1412-5. doi: 10.1126/science.1232252.
Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons were assembled, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects.
工程线框架构和支架的复杂性不断增加是纳米技术的重要挑战之一。我们提出了一种设计策略来创建类似棋盘的 DNA 结构。一系列四臂结用作双螺旋 DNA 片段网络中的顶点。故意使结从其最松弛的构象变形，以确保支架链可以从多个方向穿过各个顶点。组装了 DNA 格栅，从可重构的二维阵列到多层和三维结构以及弯曲物体。
