Institute of Vision and Optics IVO, University of Crete, Greece.
Cont Lens Anterior Eye. 2013 Oct;36(5):243-6. doi: 10.1016/j.clae.2013.02.015. Epub 2013 Mar 19.
To evaluate the efficacy of two silicone hydrogel (SiH) contact lenses, approved for continuous wear for one week, following photorefractive keratectomy (PRK).
Forty seven myopic patients (94 eyes) undergone bilateral PRK were enrolled in this prospective, double-masked, comparative study. One eye of each patient was fitted with a Lotrafilcon B lens (Ciba Vision, Duluth, US; 30-day recommended replacement) whereas the fellow eye was fitted with an Asmofilcon A lens (Menicon, Nagoya, Japan; 14-day recommended replacement). Epithelial defect size was assessed using slit lamp biomicroscopy on the day of surgery and at days 1-4 post-operatively. Uncorrected and best-corrected visual acuity and retinal straylight (C-Quant, Oculus Optigerate, Germany) were evaluated pre-operatively and one month post-operatively.
Average epithelial defect size for Asmofilcon A and Lotrafilcon B was 25.5±11.0mm(2) vs. 27.1±9.9mm(2) at day 1 (p=0.007) and 6.3±7.0mm(2) vs. 9.2±9.5mm(2) at day 2 (p=0.012) post-operatively. Re-epithelialization at day 3 was completed in 87.2% of the eyes fitted with Asmofilcon A lenses, compared to 74.5% with Lotrafilcon B lenses (p=0.012). At the 3rd post-operative day 29.8% of re-epithelialized eyes showed irregular suture with Lotrafilcon B, compared to 12.8% eyes with Asmofilcon A lenses (p<0.001). Finally, no statistically significant differences were found post-operatively between the two lenses retinal straylight (p=0.98) and best-corrected visual acuity (p=0.68).
SiH lenses can be used as an effective bandage after PRK due to the limited time requested for achieving complete corneal re-epithelialization. Faster and smoother epithelial healing is provided with Asmofilcon A over Lotrafilcon B lenses.
评估两种硅水凝胶（SiH）隐形眼镜在准分子激光角膜切削术（PRK）后的一周连续佩戴的疗效。
47 名近视患者（94 只眼）行双眼 PRK 后参与本前瞻性、双盲、对照研究。每只眼分别配戴 Lotrafilcon B 镜片（Ciba Vision，美国；推荐 30 天更换）和 Asmofilcon A 镜片（Menicon，日本；推荐 14 天更换）。术后第 1、2、3、4 天用裂隙灯显微镜观察角膜上皮缺损大小。术前及术后 1 个月分别评估未矫正视力、最佳矫正视力和视网膜散射光（C-Quant，Oculus Optigerate，德国）。
术后第 1 天，Asmofilcon A 和 Lotrafilcon B 的平均角膜上皮缺损面积分别为 25.5±11.0mm（2）和 27.1±9.9mm（2）（p=0.007），术后第 2 天分别为 6.3±7.0mm（2）和 9.2±9.5mm（2）（p=0.012）。术后第 3 天，87.2%的 Asmofilcon A 镜片眼完成再上皮化，74.5%的 Lotrafilcon B 镜片眼完成再上皮化（p=0.012）。术后第 3 天，29.8%的再上皮化眼的 Lotrafilcon B 镜片表现为不规则缝线，12.8%的 Asmofilcon A 镜片眼表现为不规则缝线（p<0.001）。最后，两种镜片的视网膜散射光（p=0.98）和最佳矫正视力（p=0.68）术后均无统计学差异。
SiH 隐形眼镜可在 PRK 后作为有效的绷带使用，因为实现完全角膜再上皮化所需的时间有限。与 Lotrafilcon B 相比，Asmofilcon A 提供更快、更平滑的上皮愈合。
