Department of Biometry and Medical Informatics, Otto-von-Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany.
Chemistry. 2013 May 10;19(20):6334-9. doi: 10.1002/chem.201203455. Epub 2013 Mar 22.
Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen-induced polarization (PHIP) is applied to enhance (19)F MR signals of (perfluoro-n-hexyl)ethene and (perfluoro-n-hexyl)ethane. Unexpectedly, the end-standing CF3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non-intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and (19)F-(19)F NOESY spectra, as well as (19)F T1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF3 group, first (19)F MR images of hyperpolarized linear semifluorinated alkenes were recorded.
氟化物在化学、工业和生命科学中都具有重要意义。在一种新方法中，采用了仲氢诱导极化（PHIP）来增强（全氟-n-己基）乙烯和（全氟-n-己基）乙烷的（19）F MR 信号。出乎意料的是，尽管与外加质子的耦合可以忽略不计，但末端的 CF3 基团表现出了最高的极化程度。为了阐明这种非直观的极化分布，比较了氘代氯仿和丙酮中的信号增强，并通过 NMR 光谱测量了（19）F-（19）F NOESY 谱和（19）F T1 值。通过使用 CF3 基团的分离和增强信号，可以首次记录到超极化线性半氟化烯烃的（19）F MR 图像。
