Bernarding Johannes, Euchner Frederike, Bruns Christian, Ringleb Rainer, Müller Darius, Trantzschel Thomas, Bargon Joachim, Bommerich Ute, Plaumann Markus
Institute for Biometrics and Medical Informatics, Otto-von-Guericke University of Magdeburg, Leipziger Strasse 44, 39120, Magdeburg, Germany.
Institute for Physical and Theoretical Chemistry, University of Bonn, Wegelerstr. 12, 53115, Bonn, Germany.
Chemphyschem. 2018 Oct 5;19(19):2453-2456. doi: 10.1002/cphc.201800570. Epub 2018 Jul 13.
Substrates containing F can serve as background-free reporter molecules for NMR and MRI. However, in vivo applications are still limited due to the lower signal-to-noise ratio (SNR) when compared with H NMR. Although hyperpolarization can increase the SNR, to date, only photo-chemically induced dynamic nuclear polarization (photo-CIDNP) allows for hyperpolarization without harmful metal catalysts. Photo-CIDNP was shown to significantly enhance F NMR signals of 3-fluoro-DL-tyrosine in aqueous solution using flavins as photosensitizers. However, lasers were used for photoexcitation, which is expensive and requires appropriate protection procedures in a medical or lab environment. Herein, we report F MR hyperpolarization at 4.7 T and 7 T with a biocompatible system using a low-cost and easy-to-handle LED-based set-up. First hyperpolarized F MR images could be acquired, because photo-CIDNP enabled repetitive hyperpolarization without adding new substrates.
含氟的底物可作为核磁共振（NMR）和磁共振成像（MRI）的无背景报告分子。然而，与氢核磁共振相比，由于信噪比（SNR）较低，其体内应用仍然有限。尽管超极化可以提高信噪比，但迄今为止，只有光化学诱导动态核极化（photo-CIDNP）能够在无有害金属催化剂的情况下实现超极化。使用黄素作为光敏剂，已证明photo-CIDNP能显著增强水溶液中3-氟-DL-酪氨酸的氟核磁共振信号。然而，激光用于光激发，成本高昂，且在医疗或实验室环境中需要适当的防护措施。在此，我们报告了在4.7 T和7 T磁场下，使用基于发光二极管（LED）的低成本且易于操作的生物相容性系统实现氟磁共振超极化。首次获得了超极化氟磁共振图像，因为photo-CIDNP能够在不添加新底物的情况下实现重复超极化。
