Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.
Endocrine. 2013 Dec;44(3):680-7. doi: 10.1007/s12020-013-9930-1. Epub 2013 Mar 27.
Omentin-1 is an adipokine implicated in diabetes, inflammation, and cardiovascular disease. However, no prospective studies have examined the impact of circulating omentin-1 levels on arterial stiffening in patients with type 2 diabetes mellitus. For the purpose of this study, we recruited 120 patients with type 2 diabetes mellitus and measured serum omentin-1, adiponectin, and high-sensitivity C-reactive protein levels as well as other cardiovascular risk factors. Arterial stiffness was assessed by brachial ankle pulse wave velocity (baPWV). An increase in the level of circulating omentin-1 over a period of 1 year was positively correlated with changes in levels of HbA1c and serum adiponectin as well as baPWV. Subjects with higher baseline serum omentin-1 levels tended to have a reduced arterial stiffness after 1 year (P for linear trend = 0.03). In the group with increased baPWV after 1 year, the magnitude of increase of circulating omentin-1 levels was significantly higher than in the group with a lower baPWV after 1 year (134.3 [16.6, 277.1] ng/mL vs. 15.9 [-67.6, 145.7] ng/mL, P < 0.01). Multiple stepwise logistic regression analysis revealed that an increase in systolic blood pressure and an increase in serum omentin-1 level were independently correlated with arterial stiffening, even after adjusting for other cardiovascular risk factors and medication history. Baseline serum omentin-1 levels can predict arterial stiffness changes occurring within a year. Furthermore, changes in serum omentin-1 levels after a year can function as independent markers of arterial stiffening in patients with type 2 diabetes mellitus.
网膜素-1 是一种与糖尿病、炎症和心血管疾病有关的脂肪因子。然而，目前还没有前瞻性研究探讨循环网膜素-1 水平对 2 型糖尿病患者动脉僵硬的影响。本研究纳入了 120 例 2 型糖尿病患者，测量了血清网膜素-1、脂联素和高敏 C 反应蛋白水平以及其他心血管危险因素。通过肱踝脉搏波速度（baPWV）评估动脉僵硬程度。1 年内循环网膜素-1水平升高与 HbA1c 和血清脂联素以及 baPWV 水平的变化呈正相关。基线血清网膜素-1 水平较高的患者在 1 年后动脉僵硬程度降低（P 趋势=0.03）。在 1 年后 baPWV 增加的患者中，循环网膜素-1 水平的增加幅度明显高于 1 年后 baPWV 降低的患者（134.3[16.6, 277.1]ng/ml 比 15.9[-67.6, 145.7]ng/ml，P<0.01）。多步逐步逻辑回归分析显示，收缩压升高和血清网膜素-1 水平升高与动脉僵硬独立相关，即使在调整了其他心血管危险因素和药物治疗史后也是如此。基线血清网膜素-1 水平可预测 1 年内动脉僵硬变化。此外，1 年后血清网膜素-1 水平的变化可作为 2 型糖尿病患者动脉僵硬的独立标志物。
