Department of Psychology, University of Connecticut, Unit 1020, Storrs, CT, USA.
J Autism Dev Disord. 2013 May;43(5):1184-95. doi: 10.1007/s10803-013-1817-8.
Autism spectrum disorder (ASD) diagnosis is based on behavioral presentation; changes in conceptual models or defining behaviors may significantly impact diagnosis and uptake of ASD-specific interventions. The literature examining impact of DSM-5 criteria is equivocal. Toddlers may be especially vulnerable to the stringent requirements of impairment in all three social-communication symptoms and two restricted/repetitive symptoms. Receiver operating characteristic (ROC) curves identified optimal cutoffs for sums of ADOS and ADI-R criteria mapped to each criterion for 422 toddlers. The optimal modification of DSM-5 criteria (sensitivity = 0.93, specificity = 0.74) required meeting the ROC-determined cutoffs for 2/3 Domain A criteria and 1 point for 1/4 Domain B criteria. This modification will help insure that ASD is identified accurately in young children, facilitating ASD-specific early intervention.
自闭症谱系障碍 (ASD) 的诊断基于行为表现；概念模型或定义行为的变化可能会对诊断和接受 ASD 特异性干预产生重大影响。关于 DSM-5 标准的影响的文献结果并不一致。幼儿可能特别容易受到严格要求的所有三个社会交往症状和两个受限/重复症状的影响。接收器操作特征 (ROC) 曲线确定了 ADOS 和 ADI-R 标准总和的最佳截断值，这些标准映射到每个标准的 422 名幼儿。DSM-5 标准的最佳修改（灵敏度= 0.93，特异性= 0.74）需要满足 ROC 确定的截断值，2/3 个域 A 标准和 1 个域 B 标准的 1 个标准。这种修改将有助于确保在幼儿中准确识别 ASD，促进 ASD 特异性早期干预。
