University of Sao Paulo, Sao Paulo, Brazil.
Arthritis Care Res (Hoboken). 2013 Sep;65(9):1449-59. doi: 10.1002/acr.22020.
To investigate the efficacy and safety of creatine supplementation in fibromyalgia patients.
A 16-week, randomized, double-blind, placebo-controlled, parallel-group trial was conducted. Fibromyalgia patients were randomly assigned to receive either creatine monohydrate or placebo in a double-blind manner. The patients were evaluated at baseline and after 16 weeks. Muscle function, aerobic conditioning, cognitive function, quality of sleep, quality of life, kidney function, and adverse events were assessed. Muscle phosphorylcreatine content was measured through (31) P magnetic resonance spectroscopy.
After the intervention, the creatine group presented higher muscle phosphorylcreatine content when compared with the placebo group (+80.3% versus -2.7%; P = 0.04). Furthermore, the creatine group presented greater muscle strength than the placebo group in the leg press and chest press exercises (+9.8% and +1.2% for creatine versus -0.5% and -7.2% for placebo, respectively; P = 0.02 and P = 0.002, respectively). Isometric strength was greater in the creatine group than in the placebo group (+6.4% versus -3.2%; P = 0.007). However, no general changes were observed in aerobic conditioning, pain, cognitive function, quality of sleep, and quality of life. Food intake remained unaltered and no side effects were reported.
Creatine supplementation increased intramuscular phosphorylcreatine content and improved lower- and upper-body muscle function, with minor changes in other fibromyalgia features. These findings introduce creatine supplementation as a useful dietary intervention to improve muscle function in fibromyalgia patients.
研究肌酸补充对纤维肌痛患者的疗效和安全性。
进行了一项为期 16 周、随机、双盲、安慰剂对照、平行组试验。纤维肌痛患者被随机分配接受肌酸单水合物或安慰剂的双盲治疗。在基线和 16 周后对患者进行评估。评估肌肉功能、有氧运动能力、认知功能、睡眠质量、生活质量、肾功能和不良事件。通过 (31) P 磁共振波谱测量肌肉磷酸肌酸含量。
干预后，与安慰剂组相比，肌酸组的肌肉磷酸肌酸含量更高（+80.3%比-2.7%；P=0.04）。此外，肌酸组在腿推和卧推练习中的肌肉力量比安慰剂组更大（肌酸分别增加+9.8%和+1.2%，而安慰剂分别减少-0.5%和-7.2%；P=0.02 和 P=0.002）。等长力量在肌酸组比安慰剂组更大（+6.4%比-3.2%；P=0.007）。然而，有氧运动能力、疼痛、认知功能、睡眠质量和生活质量没有普遍变化。食物摄入量保持不变，没有报告不良反应。
肌酸补充增加了肌肉内磷酸肌酸含量，改善了上下肢肌肉功能，对其他纤维肌痛特征仅有微小变化。这些发现表明肌酸补充作为一种有用的饮食干预措施，可改善纤维肌痛患者的肌肉功能。
