Padma Viswanadha Vijaya, Lalitha Gurusamy, Shirony Nicholson Puthanveedu, Baskaran Rathinasamy
Animal tissue culture and Molecular genetics Laboratory, Department of Biotechnology, School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore-641 046, Tamilnadu, India.
Asian Pac J Trop Biomed. 2012 Nov;2(11):910-5. doi: 10.1016/S2221-1691(12)60252-4.
To assess the effect of quercetin (flavonoid) against lindane induced alterations in lipid profile of wistar rats.
Rats were administered orally with lindane (100 mg/kg body weight) and quercetin (10 mg/kg body weight) for 30 days. After the end of treatment period lipid profile was estimated in serum and tissue.
Elevated levels of serum cholesterol, triglycerides, low density lipoprotein (LDL), very Low Density Lipoprotein (VLDL) and tissue triglycerides, cholesterol with concomitant decrease in serum HDL and tissue phospholipids were decreased in lindane treated rats were found to be significantly decreased in the quercetin and lindane co-treated rats.
Our study suggests that quercetin has hypolipidemic effect and offers protection against lindane induced toxicity in liver by restoring the altered levels of lipids. The quercetin cotreatment along with lindane for 30 days reversed these biochemical alterations in lipids induced by lindane.
评估槲皮素（类黄酮）对林丹诱导的Wistar大鼠血脂变化的影响。
大鼠口服林丹（100毫克/千克体重）和槲皮素（10毫克/千克体重），持续30天。治疗期结束后，测定血清和组织中的血脂水平。
林丹处理的大鼠血清胆固醇、甘油三酯、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）水平升高，组织甘油三酯、胆固醇升高，同时血清高密度脂蛋白（HDL）和组织磷脂降低；而在槲皮素和林丹联合处理的大鼠中，这些指标显著降低。
我们的研究表明，槲皮素具有降血脂作用，并通过恢复改变的脂质水平来保护肝脏免受林丹诱导的毒性。槲皮素与林丹共同处理30天可逆转林丹诱导的脂质生化改变。
