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一种用于共聚焦显微镜混浊成像的连贯模型。

A coherent model for turbid imaging with confocal microscopy.

作者信息

Glazowski Christopher E, Zavislan James

机构信息

Institute of Optics, University of Rochester, Rochester, NY 14627, USA.

出版信息

Biomed Opt Express. 2013 Apr 1;4(4):500-13. doi: 10.1364/BOE.4.000500. Epub 2013 Mar 4.

Abstract

We present an engineering model of coherent imaging within a turbid volume, such as human tissues, with a confocal microscope. The model is built to analyze the statistical effect of aberrations and multiply scattered light on the resulting image. Numerical modeling of theory is compared with experimental results. We describe the construction of a stable phantom that represents the statistical effect of object turbidity on the image recorded. The model and phantom can serve as basis for system optimization in turbid imaging.

摘要

我们展示了一种利用共聚焦显微镜对诸如人体组织等浑浊介质进行相干成像的工程模型。构建该模型是为了分析像差和多次散射光对最终图像的统计影响。将理论的数值模型与实验结果进行了比较。我们描述了一种稳定体模的构建,该体模体现了物体浑浊度对所记录图像的统计影响。该模型和体模可作为浑浊成像系统优化的基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5fb7/3617712/03e05d6a93cf/boe-4-4-500-g001.jpg

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