Al-Mogbel Ebtehal Solaiman
Assistant Professor, Family and Community Medicine Department, College of Medicine, Qassim University.
Int J Health Sci (Qassim). 2012 Jun;6(2):116-26. doi: 10.12816/0005987.
Vitamin D plays an important role in diverse physiological functions in addition to its role in bone health. Vitamin D deficiency is very common in elderly people, but there are few reports on its prevalence in young adults.
A cross-sectional study was carried out on a total of 465 young adult Saudi females aged 19 to 40 years old who were selected from primary health care centers of King Abdulaziz medical city, Riyadh, KSA. A questionnaire was used to identify socio-demographic characteristics and risk factors such as sunlight exposure and dietary intake. 25-hydroxy vitamin D [25(OH)D], Parathyroid hormone (PTH) and bone biochemical parameter were measured. The cutoff values for Vitamin D were defined as follows: deficient (<25nmol/L), insufficient (25-75 nmol/L) and normal (≥ 75 nmol/L).
Overall, hypovitaminosis D were identified in all participants, with a mean level of 18.34 ±8.2 nmol/L. Of all the participants, 79.1% exhibited severe vitamin D deficiency (serum 25(OH) D < 25 nmol/L), while 20.9% exhibited vitamin D insufficiency (serum 25(OH) D between 25-50 nmol/L). There was a significant inverse correlation between serum 25 (OH) D concentrations and PTH, where secondary hyperparathyroidism was evident in 61.4% of participants with deficient vitamin D compared to 39.2% of participants with insufficient vitamin D.
Despite the abundant sunlight in Saudi Arabia, the prevalence of hypovitaminosis D among young healthy Saudi females is 100%. This finding should be considered a public health problem. Case identification, health education and prevention should be encouraged.
维生素D除了在骨骼健康方面发挥作用外,还在多种生理功能中扮演重要角色。维生素D缺乏在老年人中非常普遍,但关于其在年轻人中的患病率的报道较少。
对从沙特阿拉伯利雅得阿卜杜勒阿齐兹国王医疗城的初级保健中心选取的465名年龄在19至40岁之间的沙特年轻成年女性进行了一项横断面研究。使用问卷调查来确定社会人口统计学特征和风险因素,如阳光照射和饮食摄入情况。测量了25-羟基维生素D [25(OH)D]、甲状旁腺激素(PTH)和骨生化参数。维生素D的临界值定义如下:缺乏(<25nmol/L)、不足(25 - 75 nmol/L)和正常(≥75 nmol/L)。
总体而言,所有参与者均被检测出维生素D缺乏,平均水平为18.34±8.2 nmol/L。在所有参与者中,79.1%表现为严重维生素D缺乏(血清25(OH)D < 25 nmol/L),而20.9%表现为维生素D不足(血清25(OH)D在25 - 50 nmol/L之间)。血清25(OH)D浓度与PTH之间存在显著的负相关,维生素D缺乏的参与者中有61.4%出现继发性甲状旁腺功能亢进,而维生素D不足的参与者中这一比例为39.2%。
尽管沙特阿拉伯阳光充足,但年轻健康的沙特女性中维生素D缺乏症的患病率为100%。这一发现应被视为一个公共卫生问题。应鼓励进行病例识别、健康教育和预防。