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1
The ralationship between changes in 5-HT induced platelet aggregation and clinical state in patients treated with fluphenazine.氟奋乃静治疗患者中5-羟色胺诱导的血小板聚集变化与临床状态之间的关系。
Br J Clin Pharmacol. 1976 Oct;3(5):925-8. doi: 10.1111/j.1365-2125.1976.tb00648.x.
2
Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
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Neuroleptic effects on platelet aggregation: a study in normal volunteers and schizophrenics.抗精神病药物对血小板聚集的影响：一项在正常志愿者和精神分裂症患者中的研究。
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Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.氯丙嗪及其代谢产物对5-羟色胺诱导的人血小板聚集的抑制作用。
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Haloperidol decanoate as a replacement for maintenance therapy with intramuscular fluphenazine decanoate in schizophrenia and other chronic psychoses.癸酸氟哌啶醇替代癸酸氟奋乃静进行精神分裂症及其他慢性精神病的维持治疗。
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Serotonin receptor site in human platelets from control and chlorpromazine treated subjects.来自对照受试者和氯丙嗪治疗受试者的人血小板中的血清素受体位点。
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Resuspension of platelets: enhanced 5-hydroxytryptamine-induced aggregation in chlorpromazine treated patients due to changes in platelet properties.血小板再悬浮：由于血小板特性改变，氯丙嗪治疗的患者中5-羟色胺诱导的聚集增强。
Br J Clin Pharmacol. 1975 Feb;2(1):37-9. doi: 10.1111/j.1365-2125.1975.tb00469.x.

引用本文的文献

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Idiopathic pulmonary thromboembolism in the course of intensive psychiatric inpatient care: case report and treatment guidelines.重症精神科住院治疗过程中的特发性肺血栓栓塞症：病例报告及治疗指南
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Antipsychotic-induced venous thromboembolism: a review of the evidence.抗精神病药物所致静脉血栓栓塞：证据综述
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The effects of neuroleptic drugs on 5-hydroxytryptamine induced platelet aggregation in schizophrenic patients.抗精神病药物对精神分裂症患者5-羟色胺诱导的血小板聚集的影响。
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Experientia. 1988 Feb 15;44(2):142-5. doi: 10.1007/BF01952198.
8
Increased platelet membrane [3H]-LSD binding in patients on chronic neuroleptic treatment.长期接受抗精神病药物治疗的患者血小板膜[3H]-麦角酰二乙胺结合增加。
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9
Platelet aggregation and chlorpromazine therapy.血小板聚集与氯丙嗪治疗
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本文引用的文献

1
The mechanism of adenosine diphosphate induced platelet aggregation: binding to platelet receptors and inhibition of binding and aggregation by prostaglandin E 1 .二磷酸腺苷诱导血小板聚集的机制：与血小板受体结合以及前列腺素E1对结合和聚集的抑制作用。
J Physiol. 1972 Mar;221(2):415-26. doi: 10.1113/jphysiol.1972.sp009758.
2
Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.氯丙嗪及其代谢产物对5-羟色胺诱导的人血小板聚集的抑制作用。
Br J Pharmacol. 1975 Jan;53(1):121-5. doi: 10.1111/j.1476-5381.1975.tb07338.x.
3
Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
Br J Clin Pharmacol. 1975 Feb;2(1):29-35. doi: 10.1111/j.1365-2125.1975.tb00468.x.
4
The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets.三氟噻吨对5-羟色胺诱导的人血小板聚集以及5-羟色胺和多巴胺摄取的作用。
Br J Pharmacol. 1975 Dec;55(4):555-7. doi: 10.1111/j.1476-5381.1975.tb07432.x.

氟奋乃静治疗患者中5-羟色胺诱导的血小板聚集变化与临床状态之间的关系。

The ralationship between changes in 5-HT induced platelet aggregation and clinical state in patients treated with fluphenazine.

作者信息

Orr M W, Boullin D J

出版信息

Br J Clin Pharmacol. 1976 Oct;3(5):925-8. doi: 10.1111/j.1365-2125.1976.tb00648.x.

DOI:10.1111/j.1365-2125.1976.tb00648.x
PMID:973988
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1428938/
Abstract

Platelet aggregation responses to 5-HT and adenosine diphosphate were examined in a population of eighteen patients treated with fluphenazine decanoate for longer than one year. 5-HT induced aggregation was enhanced in ten subjects. This enhancement was similar to that previously described in patients receiving chlorpromazine. Patients who showed enhanced 5-HT induced aggregation showed less rateable psychopathology and less extrapyramidal side-effects than patients who did not show enhancement. These findings suggest that platelet aggregation responses could be used to identify patients who could be safely withdrawn from long-term neuroleptic therapy.

摘要

在18名接受癸酸氟奋乃静治疗超过一年的患者群体中，检测了血小板对5-羟色胺（5-HT）和二磷酸腺苷的聚集反应。10名受试者中5-HT诱导的聚集增强。这种增强与先前在接受氯丙嗪治疗的患者中所描述的相似。与未表现出增强的患者相比，表现出5-HT诱导聚集增强的患者的精神病理学症状和锥体外系副作用较少。这些发现表明，血小板聚集反应可用于识别能够安全停用长期抗精神病药物治疗的患者。