氟奋乃静治疗患者中5-羟色胺诱导的血小板聚集变化与临床状态之间的关系。
The ralationship between changes in 5-HT induced platelet aggregation and clinical state in patients treated with fluphenazine.
作者信息
Orr M W, Boullin D J
出版信息
Br J Clin Pharmacol. 1976 Oct;3(5):925-8. doi: 10.1111/j.1365-2125.1976.tb00648.x.
Abstract
Platelet aggregation responses to 5-HT and adenosine diphosphate were examined in a population of eighteen patients treated with fluphenazine decanoate for longer than one year. 5-HT induced aggregation was enhanced in ten subjects. This enhancement was similar to that previously described in patients receiving chlorpromazine. Patients who showed enhanced 5-HT induced aggregation showed less rateable psychopathology and less extrapyramidal side-effects than patients who did not show enhancement. These findings suggest that platelet aggregation responses could be used to identify patients who could be safely withdrawn from long-term neuroleptic therapy.
摘要
在18名接受癸酸氟奋乃静治疗超过一年的患者群体中，检测了血小板对5-羟色胺（5-HT）和二磷酸腺苷的聚集反应。10名受试者中5-HT诱导的聚集增强。这种增强与先前在接受氯丙嗪治疗的患者中所描述的相似。与未表现出增强的患者相比，表现出5-HT诱导聚集增强的患者的精神病理学症状和锥体外系副作用较少。这些发现表明，血小板聚集反应可用于识别能够安全停用长期抗精神病药物治疗的患者。
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本文引用的文献
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The mechanism of adenosine diphosphate induced platelet aggregation: binding to platelet receptors and inhibition of binding and aggregation by prostaglandin E 1 .二磷酸腺苷诱导血小板聚集的机制：与血小板受体结合以及前列腺素E1对结合和聚集的抑制作用。
J Physiol. 1972 Mar;221(2):415-26. doi: 10.1113/jphysiol.1972.sp009758.
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Inhibition of 5-hydroxytryptamine-induced human blood platelet aggregation by chlorpromazine and its metabolites.氯丙嗪及其代谢产物对5-羟色胺诱导的人血小板聚集的抑制作用。
Br J Pharmacol. 1975 Jan;53(1):121-5. doi: 10.1111/j.1476-5381.1975.tb07338.x.
3
Increased platelet aggregation responses to 5-hydroxytryptamine in patients taking chlorpromazine.服用氯丙嗪的患者对5-羟色胺的血小板聚集反应增强。
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The actions of flupenthixol upon 5-hydroxytryptamine-induced aggregation and the uptake of 5-hydroxytryptamine and dopamine by human blood platelets.三氟噻吨对5-羟色胺诱导的人血小板聚集以及5-羟色胺和多巴胺摄取的作用。
Br J Pharmacol. 1975 Dec;55(4):555-7. doi: 10.1111/j.1476-5381.1975.tb07432.x.
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