Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
Obes Surg. 2013 Jul;23(7):1011-5. doi: 10.1007/s11695-013-0953-8.
Obesity is a risk factor for heart failure (HF), but the benefit of weight loss in HF is unknown. We assessed the effects of bariatric surgery (BSx) compared to non-operative treatment for morbid obesity on overall quality of life (QoL), functional capacity, and symptoms in 13 HF patients undergoing BSx and six HF patients treated without surgery. In the BSx group, median age was 62, body mass index (BMI) was 55 kg/m(2), and 5/13 were males; in the non-operative group, median age was 69, BMI was 42 kg/m(2), and 1/6 were male. Median follow-up was 4.3 and 2.7 years, respectively. At follow-up, BMI was less in the BSx group (35 vs 47 kg/m(2), p < 0.001); QoL (p < 0.01), frequency of exertional dyspnea (p = 0.01), and leg edema (p = 0.04) improved only in the BSx group. BSx induced weight loss and improved QoL and symptoms in morbidly obese patients with HF.
肥胖是心力衰竭(HF)的一个危险因素,但减肥对 HF 的益处尚不清楚。我们评估了肥胖症患者接受减肥手术(BSx)与非手术治疗相比对整体生活质量(QoL)、功能能力和症状的影响,共纳入 13 例接受 BSx 的 HF 患者和 6 例未接受手术的 HF 患者。BSx 组的中位年龄为 62 岁,体重指数(BMI)为 55kg/m²,5/13 为男性;非手术组的中位年龄为 69 岁,BMI 为 42kg/m²,1/6 为男性。BSx 组和非手术组的中位随访时间分别为 4.3 年和 2.7 年。随访时,BSx 组的 BMI 明显低于非手术组(35 与 47kg/m²,p<0.001);BSx 组的 QoL(p<0.01)、劳力性呼吸困难发作频率(p=0.01)和腿部水肿(p=0.04)明显改善,而非手术组无明显变化。BSx 可诱导体重减轻,并改善肥胖合并 HF 患者的 QoL 和症状。