Breitholtz-Emanuelsson A, Minervini F, Hult K, Visconti A
Consiglio Nazionale delle Ricerche, Istituto Tossine e Micotossine da Parassiti Vegetali, Bari, Italy.
Nat Toxins. 1994;2(6):366-70.
Ochratoxin A was determined in human serum samples, collected in the south of Italy in November 1992, using ion-pair liquid chromatography and fluorescence detection. The samples were collected from healthy people (65 subjects) as well as from people with different kidney disorders. Five different kinds of kidney disorders were represented: transplanted subjects (13), chronic glomerulonephritis (8), renal calculus or cyst (6), chronic renal failure (13), and subjects treated by dialysis (28). The mean and median concentrations of ochratoxin A in the healthy group was 0.53 and 0.44 ng/ml serum, respectively. The highest mean concentration was found in the group of patients treated by dialysis, 1.4 ng/ml serum. A higher incidence of samples containing > 0.44 ng ochratoxin A/ml serum was found in the dialysis group, compared to the other groups. Comparing the mean concentrations by Student's t-test, a significant difference was found between the mean concentrations of the healthy group and of the group of patients treated by dialysis (P < 0.01). No other significant differences were found when comparing the groups two at a time.
采用离子对液相色谱法和荧光检测法，对1992年11月在意大利南部采集的人体血清样本中的赭曲霉毒素A进行了测定。样本采集自健康人群（65名受试者）以及患有不同肾脏疾病的人群。其中包括五种不同类型的肾脏疾病：肾移植患者（13例）、慢性肾小球肾炎患者（8例）、肾结石或肾囊肿患者（6例）、慢性肾衰竭患者（13例）以及接受透析治疗的患者（28例）。健康组中赭曲霉毒素A的平均浓度和中位数浓度分别为0.53 ng/ml血清和0.44 ng/ml血清。透析治疗组患者的平均浓度最高，为1.4 ng/ml血清。与其他组相比，透析组中赭曲霉毒素A含量>0.44 ng/ml血清的样本发生率更高。通过学生t检验比较平均浓度发现，健康组与透析治疗组的平均浓度之间存在显著差异（P<0.01）。每次对两组进行比较时，未发现其他显著差异。
