Institute of Animal Science and Veterinary Medicine, Hubei Academy of Agricultural Sciences, Yaoyuan No. 1, Nanhu, Hongshan District, Wuhan, 430064, People's Republic of China.
J Appl Genet. 2013 Aug;54(3):271-83. doi: 10.1007/s13353-013-0148-y. Epub 2013 Apr 23.
Although the majority of genes are expressed equally from both alleles, some genes are differentially expressed. Organisms possess characteristics to preferentially express a particular allele under regulatory factors, which is termed allele-specific expression (ASE). It is one of the important genetic factors that lead to phenotypic variation and can be used to identify the variance of gene regulation factors. ASE indicates mechanisms such as DNA methylation, histone modifications, and non-coding RNAs function. Here, we review a broad survey of progress in ASE studies, and what this simple yet very effective approach can offer in functional genomics, and possible implications toward our better understanding of the underlying mechanisms of complex traits.
尽管大多数基因都从两个等位基因平等表达，但有些基因是差异表达的。生物体具有在调节因子下优先表达特定等位基因的特性，这被称为等位基因特异性表达（ASE）。它是导致表型变异的重要遗传因素之一，可用于鉴定基因调控因子的变异。ASE 表明了 DNA 甲基化、组蛋白修饰和非编码 RNA 等机制的作用。在这里，我们综述了 ASE 研究进展的广泛调查，以及这种简单而非常有效的方法在功能基因组学中能提供什么，并对我们更好地理解复杂性状的潜在机制可能产生的影响。
