Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
Nat Rev Cancer. 2013 May;13(5):357-65. doi: 10.1038/nrc3497.
The ageing of populations worldwide is leading to an unprecedented increase in cancer cases and fatalities. Understanding the links between cancer and ageing is therefore more important than ever. How the interplay of ageing-associated changes affects cancer initiation and progression is complex, however, and some ageing processes probably foster cancer development whereas others hinder it, possibly in a tissue-specific manner. In the emerging age of cancer, how can our growing understanding of the biology of ageing inform cancer biology?
全球人口老龄化正导致癌症病例和死亡人数的空前增加。因此，了解癌症与衰老之间的联系比以往任何时候都更加重要。然而，衰老相关变化的相互作用如何影响癌症的发生和发展是复杂的，一些衰老过程可能促进癌症的发展，而另一些则可能以组织特异性的方式阻碍癌症的发展。在癌症的新兴时代，我们对衰老生物学日益增长的认识如何为癌症生物学提供信息？
